ALP70
Apolipoprotein E, human
Synonym(s):
ApoE
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 μg | Check Cart for Availability | $419.00 |
About This Item
UNSPSC Code:
12352202
NACRES:
NA.41
eCl@ss:
32160405
Form:
liquid
Assay:
≤95% (SDS-PAGE)
Biological source:
human
biological source
human
Quality Level
assay
≤95% (SDS-PAGE)
form
liquid
manufacturer/tradename
Chemicon®
concentration
0.276 mg/mL
NCBI accession no.
UniProt accession no.
General description
Apolipoprotein E (Apo E) is a multifunctional protein and exists in 3 isoforms namely apoE2, apoE3, and apoE4. It is the constituent of plasma lipoproteins. Apo E is produced by various tissues and is majorly found in interstitial fluid and lymph. It is released in a lipid-poor form.[1]
Application
Apolipoprotein E, human has been used as a standard for the quantification of ApoE protein in the sucrose density gradient (SDG) fractions and the unfractionated brain homogenates using an in-house developed sandwich enzyme-linked immunosorbent assay (ELISA).[2] It has also been used in western blotting to assess its exogenous effects on low-density lipoprotein (LDL)-heparin interactions.[3]
Biochem/physiol Actions
Apolipoprotein E (Apo E) serves as a ligand for low-density receptors and participates in the transport and redistribution of cholesterol and other lipids.[4] It is thought to be involved in tissue repair as increased amounts of the protein are found at sites or peripheral nerve injury and regeneration.[1] A mutant form is associated with type III hyperlipoproteinemia.[4] Apo E plays a crucial role in neurobiology and neurodegenerative diseases.[1]
Physical form
Liquid in 10 mM NH4HCO3, pH 8.0.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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This Item | |||
|---|---|---|---|
| assay ≤95% (SDS-PAGE) | assay >95% (SDS-PAGE) | assay ≥95% (SDS-PAGE) | assay ≥95% (SDS-PAGE) |
| biological source human | biological source human | biological source human plasma | biological source - |
| concentration 0.276 mg/mL | concentration - | concentration - | concentration - |
| form liquid | form liquid | form frozen liquid | form liquid |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. - |
| NCBI accession no. | NCBI accession no. | NCBI accession no. - | NCBI accession no. - |
Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Yadong Huang et al.
Neurobiology of disease, 72 Pt A, 3-12 (2014-09-01)
Apolipoprotein (apo) E is a multifunctional protein with central roles in lipid metabolism, neurobiology, and neurodegenerative diseases. It has three major isoforms (apoE2, apoE3, and apoE4) with different effects on lipid and neuronal homeostasis. A major function of apoE is
Zaili Yang et al.
Journal of virology, 90(21), 9632-9643 (2016-08-19)
Hepatitis C virus (HCV) is a major cause of chronic liver disease, infecting approximately 170 million people worldwide. HCV assembly is tightly associated with the lipoprotein pathway. Exchangeable apolipoprotein E (apoE) is incorporated on infectious HCV virions and is important
Paul S Hauser et al.
Progress in lipid research, 50(1), 62-74 (2010-09-22)
Apolipoprotein (apo) E has a storied history as a lipid transport protein. The integral association between cholesterol homeostasis and lipoprotein clearance from circulation are intimately related to apoE's function as a ligand for cell-surface receptors of the low-density lipoprotein receptor
Global Trade Item Number
| SKU | GTIN |
|---|---|
| ALP70-50UG | 04053252273414 |