This product has been qualified for use with serum or plasma samples. The end user would have to determine suitability with urine.
EZHGIP
Human GIP ELISA Kit
measures and quantify total GIP levels in 20 μL serum, plasma or cell culture samples
Synonym(s):
Gastric inhibitory polypeptide, Glucose-dependent insulinotropic polypeptide, Incretin hormone
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About This Item
UNSPSC Code:
12161503
eCl@ss:
32161000
NACRES:
NA.32
Gene information:
human ... GNAI2(2771)
Input:
sample type cell culture supernatant
sample type serum
sample type plasma (K2 EDTA)
sample type serum
sample type plasma (K2 EDTA)
Assay range:
accuracy: 86.7%
linearity: 99.9%
sensitivity: 8.2 pg/mL
standard curve range: 8.2-2000 pg/mL
linearity: 99.9%
sensitivity: 8.2 pg/mL
standard curve range: 8.2-2000 pg/mL
Species reactivity:
human
Storage temp.:
2-8°C
Shipped in:
wet ice
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Product Name
Human GIP (total) ELISA, This Human GIP (total) ELISA is used to measure & quantify GIP levels in Metabolism & Endocrine research.
species reactivity
human
packaging
kit of 1 × 96 wells
parameter
20 μL sample volume (4hr assay)
assay range
accuracy: 86.7%
linearity: 99.9%
sensitivity: 8.2 pg/mL
standard curve range: 8.2-2000 pg/mL
technique(s)
ELISA: suitable
input
sample type cell culture supernatant
sample type serum
sample type plasma (K2 EDTA)
NCBI accession no.
UniProt accession no.
application(s)
research use
detection method
colorimetric (450nm/590nm)
shipped in
wet ice
storage temp.
2-8°C
Quality Level
Gene Information
human ... GNAI2(2771)
1 of 4
This Item | EZRMGIP | EZGRT | EZHI |
|---|---|---|---|
| species reactivity human | species reactivity mouse, rat | species reactivity human | species reactivity human |
| Gene Information human ... GNAI2(2771) | Gene Information - | Gene Information - | Gene Information - |
| assay range accuracy: 86.7%, sensitivity: 8.2 pg/mL, linearity: 99.9%, standard curve range: 8.2-2000 pg/mL | assay range accuracy: 104.2%, linearity: 100.8%, sensitivity: 8.2 pg/mL, standard curve range: 8.2-2000 pg/mL | assay range accuracy: 101-107% | assay range accuracy: 76-103%, linearity: 96-112%, standard curve range: 2-200 μU/mL |
| input sample type cell culture supernatant | input sample type cell culture supernatant | input sample type plasma (K2 EDTA) | input sample type plasma (K2 EDTA) |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| technique(s) ELISA: suitable | technique(s) ELISA: suitable | technique(s) ELISA: suitable | technique(s) ELISA: suitable |
Application
Human GIP (total) ELISA has been used to measure total glucose-dependent insulinotropic polypeptide (GIP) in blood samples.
Disclaimer
For research use only. Not for use in diagnostic procedures.
General description
GIP, also known as a gastric inhibitory polypeptide, or glucose-dependent insulinotropic polypeptide is encoded by the gene mapped to human chromosome 17q12-q21. It is synthesized in and secreted from K cells in the intestinal epithelium. GIP secretion from the gastrointestinal tract plays a major role in glucose homeostasis. It stimulates insulin secretion from pancreatic β cells after oral ingestion of nutrients. In addition, GIP also promotes insulin biosynthesis, and β-cell proliferation and alleviates beta-cell apoptosis GIP also aids in fat metabolism by stimulating triglyceride synthesis in adipocytes. Elevated levels of GIP may lead to obesity and hyperinsulinemia. This Human GIP (total) ELISA is used to measure & quantify GIP levels in Metabolism & Endocrine research.
Other Notes
Research Sub Category Obesity Metabolic Disorders Room temperature, 3.5 hour assay, 20 µL sample volume, serum, plasma, or tissue culture medium Research Category Metabolism
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Met. Corr. 1 - Skin Sens. 1
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
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L A Anderson et al.
Genomics, 17(3), 618-623 (1993-09-01)
To facilitate the positional cloning of the breast-ovarian cancer gene BRCA1, we constructed a high-density genetic map of the 8.3-cM interval between D17S250 and GIP on chromosome 17q12-q21. Markers were mapped by linkage in the CEPH and in extended kindreds
Dietary sugars stimulate fatty acid synthesis in adults.
Elizabeth J Parks, Lauren E Skokan, Maureen T Timlin, Carlus S Dingfelder
The Journal of Nutrition null
Tsuyoshi Yanagimachi et al.
Molecular metabolism, 6(2), 226-231 (2017-02-10)
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) possess multiple bioactive isoforms that are rendered non-insulinotropic by the enzyme dipeptidyl peptidase-4 (DPP-4). Recently, some ELISA kits have been developed to specifically measure "active" GIP and GLP-1, but it is unclear
Colesevelam improves oral but not intravenous glucose tolerance by a mechanism independent of insulin sensitivity and ?-cell function.
Anna L Marina,Kristina M Utzschneider,Lorena A Wright,Brenda K Montgomery et al.
Diabetes Care null
Frank Isken et al.
American journal of physiology. Endocrinology and metabolism, 295(2), E350-E355 (2008-05-29)
Menopause and premature gonadal steroid deficiency are associated with increases in fat mass and body weight. Ovariectomized (OVX) mice also show reduced locomotor activity. Glucose-dependent-insulinotropic-polypeptide (GIP) is known to play an important role both in fat metabolism and locomotor activity.
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What is the sample type? Urine?
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What is the CAS numbers for this product - it does not appear on the SDS
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This item is a multi-component product. A CAS number cannot be applied to this type of product. The Safety Data Sheet document includes the individual CAS numbers of those components that may be potentially hazardous.
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