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HCVD2MAG-67K

Millipore

MILLIPLEX® Human Cardiovascular Disease (CVD) Magnetic Bead Panel 2 - Cardiovascular Disease Multiplex Assay

The analytes available for this multiplex kit are: ADAMTS13, D-Dimer, GDF-15, Myoglobin, sICAM-1, MPO, P-selectin, Lipocalin-2/NGAL, sVCAM-1, SAA.

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eCl@ss:
32161000

Quality Level

species reactivity

human

manufacturer/tradename

Milliplex®

assay range

accuracy: 88%
(Myoglobin)

accuracy: 90%
(P-selectin)

accuracy: 98%
(GDF-15)

standard curve range: 0.0005-2.5 ng/mL
(GDF-15)

standard curve range: 0.012-50 ng/mL
(Lipocalcin-2/NGAL)

standard curve range: 0.024-100 ng/mL
(Myoglobin & MPO)

standard curve range: 0.085-350 ng/mL
(sICAM-1)

standard curve range: 0.122-500 ng/mL
(sVCAM-1)

standard curve range: 0.244-1,000 ng/mL
(D-dimer, SAA & P-selectin)

standard curve range: 1.221-5,000 ng/mL
(ADAMTS 13)

inter-assay cv: <20%
intra-assay cv: <15%

technique(s)

multiplexing: suitable

detection method

fluorometric (Luminex xMAP)

shipped in

wet ice

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HCVD1MAG-67KHCVD6MAG-67KHCVD4MAG-67K
manufacturer/tradename

Milliplex®

manufacturer/tradename

Milliplex®

manufacturer/tradename

Milliplex®

manufacturer/tradename

Milliplex®

assay range

accuracy: 88%
(Myoglobin), accuracy: 90%
(P-selectin), accuracy: 98%
(GDF-15), standard curve range: 0.0005-2.5 ng/mL
(GDF-15), standard curve range: 0.012-50 ng/mL
(Lipocalcin-2/NGAL), standard curve range: 0.024-100 ng/mL
(Myoglobin & MPO), standard curve range: 0.085-350 ng/mL
(sICAM-1), standard curve range: 0.122-500 ng/mL
(sVCAM-1), standard curve range: 0.244-1,000 ng/mL
(D-dimer, SAA & P-selectin), standard curve range: 1.221-5,000 ng/mL
(ADAMTS 13), inter-assay cv: <20%
intra-assay cv: <15%

assay range

accuracy: 100%
(CK-MB), accuracy: 102%
(LIGHT), accuracy: 102%
(Oncostatin (OSM)), accuracy: 103%
(CXCL6/GCP-2), accuracy: 96%
(FABP3), accuracy: 96%
(Placental Growth Factor (PlGF)), accuracy: 97%
(NT proBNP), standard curve range: 137.2-100,000 pg/mL
(FABP3), standard curve range: 2.7-2,000 pg/mL
(Placental Growth Factor (PlGF)), standard curve range: 34.3-25,000 pg/mL
(NT proBNP, CXCL16, Endocan-1 (ESM-1), LIGHT), standard curve range: 6.9-5,000 pg/mL
(CXCL6, Oncostatin (OSM)), standard curve range: 68.6-50,000 pg/mL
(BNP, CK-MB, Troponin I (TnI)), standard curve range: 685.9-500,000 pg/mL
(FABP4), inter-assay cv: <20%
intra-assay cv: <10%

assay range

accuracy: 92%
(Endostatin), accuracy: 95%
(ucMGP), accuracy: 97%
(DPP4/sCD26), sensitivity: 0.007 ng/mL
(MinDC+2SD; Endostatin), sensitivity: 0.014 ng/mL
(MinDC+2SD; pGRN), sensitivity: 0.015 ng/mL
(MinDC+2SD; LRG1), sensitivity: 0.016 ng/mL
(MinDC+2SD; MCAM), sensitivity: 0.016 ng/mL
(MinDC+2SD; sCD14), sensitivity: 0.041 ng/mL
(MinDC+2SD; DPP4), sensitivity: 0.052 ng/mL
(MinDC+2SD; ucMGP), standard curve range: 0.002-10 ng/mL
(Endostatin), standard curve range: 0.01-40 ng/mL
(sCD14), standard curve range: 0.024-100 ng/mL
(LRG1), standard curve range: 0.024-100 ng/mL
(MCAM), standard curve range: 0.024-100 ng/mL
(pGRN), standard curve range: 0.049-200 ng/mL
(DPP4/sCD26), standard curve range: 0.049-200 ng/mL
(ucMGP), inter-assay cv: <10%
intra-assay cv: <5%
(DPP4/sCD26), inter-assay cv: <10%
intra-assay cv: <5%
(Endostatin), inter-assay cv: <10%
intra-assay cv: <5%
(LRG1), inter-assay cv: <10%
intra-assay cv: <5%
(MCAM), inter-assay cv: <10%
intra-assay cv: <5%
(pGRN), inter-assay cv: <20%
intra-assay cv: <10%
(ucMGP), inter-assay cv: <20%
intra-assay cv: <5%
(sCD14)

assay range

accuracy: 103%
(Thrombomodulin), accuracy: 104%
(Pentraxin-3 (PTX3)), accuracy: 104%
(Tissue Factor (TF)), accuracy: 106%
(Pecam-1), accuracy: 109%
(sE-Selectin), standard curve range: 0.01-5 ng/mL
(Troponin T (TnT)), standard curve range: 0.04-30 ng/mL
(Follistatin (FST)), standard curve range: 0.14-100 ng/mL
(Pentraxin-3 (PTX3) & Tissue Factor (TF)), standard curve range: 0.27-200 ng/mL
(Pecam-1), standard curve range: 0.34-250 ng/mL
(Thrombomodulin), standard curve range: 2.7-2,000 ng/mL
(sE-Selectin), inter-assay cv: <20%
intra-assay cv: <10%

technique(s)

multiplexing: suitable

technique(s)

multiplexing: suitable

technique(s)

multiplexing: suitable

technique(s)

multiplexing: suitable

detection method

fluorometric (Luminex xMAP)

detection method

fluorometric (Luminex xMAP)

detection method

fluorometric (Luminex xMAP)

detection method

fluorometric (Luminex xMAP)

shipped in

wet ice

shipped in

wet ice

shipped in

ambient

shipped in

wet ice

General description

Cardiovascular disease, particularly atherosclerotic vascular disease, is a leading cause of global mortality, accounting for 30% of all global deaths (WHO, 2010). Inflammatory mechanisms play a vital role in the initiation, maintenance, and progression of vascular disease with a strong correlation between inflammatory markers and prognosis in acute and chronic coronary artery disease. Numerous studies have demonstrated an association of obesity and diabetes with cardiovascular risk factors.

MILLIPLEX® Human Cardiovascular Disease (CVD) Panel 2 is a 10-plex kit to be used for the simultaneous quantification of any or all of the following analytes in human serum, plasma and tissue/cell lysate and culture supernatant samples: Adamts13, D-dimer, GDF-15, Myoglobin, sICAM-1, MPO, P-selectin, Lipocalin-2/NGAL, sVCAM-1 and SAA. This kit uses a 96-well format, contains a lyophilized standard cocktail, two internal assay quality controls and can measure up to 38 samples in duplicate.

The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.

Panel Type: Cardiovascular

Specificity

Cross Reactivty
There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes in this panel.

Application

  • Analytes: ADAMTS13, D-Dimer, GDF15, sICAM-1, Myeloperoxidase (MPO), Myoglobin, NGAL/Lipocalin-2, sP-selectin, Serum Amyloid A (SAA), sVCAM-1
  • Recommended Sample Type: Human serum, plasma, cell/tissue culture supernatants and lysates
  • Recommended Sample Dilution: 25 μL per well of 1:100 diluted serum or plasma; tissue/cell culture samples may require dilution in appropriate control medium
  • NOTE: D-Dimer cannot be measured in plasma samples
  • Assay Run Time: Overnight (16-18 hours) at 2-8°C or 2 hours at room temperature (20-25 °C)
  • Research Category: Cardiovascular Disease
  • Research Subcategory: Metabolic Disorders

Features and Benefits

Design your multiplex kit by choosing available analytes within this panel.

Other Notes

Please contact Technical Service for linearity of dilution.
Sensitivity: See kit protocol for individual analytes sensitive’s.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pictograms

Exclamation markEnvironment

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

10 - Combustible liquids

WGK

WGK 3


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Carolina López-Cano et al.
PloS one, 14(2), e0211742-e0211742 (2019-02-06)
Subjects with sleep apnea-hypopnea syndrome (SAHS) show an increased carotid intima-media thickness. However, no data exist about earlier markers of atheromatous disease, such as the proliferation and expansion of the adventitial vasa vasorum (VV) to the avascular intima in this
Priscila Valéria do Carmo Carvalho et al.
Revista da Sociedade Brasileira de Medicina Tropical, 51(3), 277-283 (2018-07-05)
Mortality among HIV patients is 3-15 times higher than that among the general population. Currently, most deaths are due to non-infectious diseases. Chronic inflammation and adverse events due to antiretroviral therapy play crucial roles in increasing cardiovascular risk (CVR). This
Riccardo Calvani et al.
Journal of cachexia, sarcopenia and muscle, 8(1), 69-77 (2016-11-30)
Chronic inflammation, changes in body composition, and declining physical function are hallmarks of the ageing process. The aim of the present study was to provide a preliminary characterisation of the relationship among these age-related phenomena via multivariate modelling. Thirty-five old
Rebeca Quirós-Fernández et al.
Nutrients, 11(3) (2019-03-20)
Hydroxytyrosol (HT) and Punicalagin (PC) exert cardioprotective and anti-atherosclerotic effects. This study evaluates the effect of oral supplementation with HT and PC (SAx) on early atherosclerosis markers in middle-aged, seemingly healthy adults. A randomized, double-blinded, placebo-controlled, crossover trial was performed
Kiara C S Zapponi et al.
Journal of thrombosis and thrombolysis (2021-08-28)
Neutrophil activation and neutrophil extracellular traps (NETs) have been associated with the pathogenesis of venous thromboembolism (VTE). Considering VTE-associated chronic sequelae, which suggest that some pathological mechanisms remain after the acute episode, we investigated whether neutrophil activation is increased in

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