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MILLIPLEX® Human Cytokine Autoantibody IgM Kit

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species reactivity

human

Quality Level

manufacturer/tradename

Milliplex®

technique(s)

multiplexing: suitable

detection method

fluorometric (Luminex® xMAP®)

storage temp.

2-8°C

General description

Anti-cytokine antibodies occur frequently and are present in healthy individuals and in individuals with acquired immunodeficiency and autoimmune diseases. Cytokines offering protection against microbes can be targeted by cytokine autoantibodies, leading to life-threatening infections. Some infections associated with anti-cytokine antibodies include M. tuberculosis, Salmonella, S. aureus. E. coli, Histoplasma, and more. The presence of cytokine autoantibodies in autoimmune disease can influence disease severity and activity. These autoimmune diseases may include systemic lupus erythematosus, multiple sclerosis, Sjögren’s syndrome, rheumatoid arthritis, and acute respiratory distress syndrome. Measuring cytokine autoantibodies may be useful for disease monitoring and efficacy of treatment.

The MILLIPLEX® Human Cytokine Autoantibody IgM Magnetic Bead Panel is a 23-plex kit to be used for the simultaneous detection of any or all of the analytes listed below in serum and plasma samples.

Application

The MILLIPLEX® Human Cytokine Autoantibody IgM Panel is a bead-based qualitative assay based on the Luminex® xMAPxmap® technology, which enables the simultaneous analysis of cytokine autoantibodies in human serum and plasma samples.

Panel Type:
MAGNETIC Immune Response

Analytes Available: Anti-BAFF, Anti-G-CSF, Anti-IFNβ, Anti-IFNγ, Anti-IL-1α, Anti-IL-6, Anti IL 8, Anti-IL-10, Anti-IL-12p40, Anti-IL-15, Anti-IL-17A, Anti-IL-17F, Anti-IL-18, Anti-IL-22, Anti-TNFα, Anti-IFNα2, Anti-GM-CSF, Anti-IL-2, Anti-IL-3, Anti-IL-4, Anti-Osteopontin, Anti-PF4, and Anti-IFNω.

Cross Reactivity:
There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes in this panel.

Research Area: Inflammation & Immunology

Research Sub-Category: Inflammation & Autoimmune Mechanisms; Inflammation

Features and Benefits

Design your multiplex kit by choosing available analytes within this panel.

Packaging

96-well plate

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Warning

Hazard Classifications

Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1

Storage Class

10 - Combustible liquids

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WGK 3


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