Fibrosis is a pathological wound healing response that is common to many chronic diseases and injuries. The abnormal wound healing response of fibrosis involves the excessive accumulation of the extracellular matrix components responsible for the formation of scar tissue. Progressive tissue scarring causes alterations to normal organ structure leading to dysfunction and failure. Fibrosis and related diseases are responsible for an increasing burden of morbidity and mortality worldwide. This panel of fibrosis-related biomarkers enables researchers to advance understanding of the complex processes associated with fibrotic diseases, including but not limited to idiopathic pulmonary fibrosis, liver fibrosis, and lung fibrosis.
Human Fibrosis Panel 1 is a 3-plex kit to be used for the simultaneous quantification of any or all of the following analytes in serum, plasma and tissue culture samples:
IL-18 Binding Protein A (IL-18BPa), Cartilage Oligomeric Matrix Protein (COMP), and Uteroglobin.
offers the broadest selection of analytes across a wide range of disease states and species. Once the analytes of interest have been identified, you can rely on the quality that we build into each kit to produce results you can trust. In addition to the assay characteristics listed in the protocol, other performance criteria evaluated during the verification process include: cross-reactivity, dilution linearity, kit stability, and sample behavior (e.g. detectability and stability).
panel and kit includes:
- Quality controls (QCs) to qualify assay performance
- Comparison of standard (calibrator) and QC lots to a reference lot to ensure lot-to-lot consistency
- Optimized serum matrix to mimic native analyte environment in serum and plasma samples
- Detection antibody cocktails designed to yield consistent analyte profiles within panel
In addition each panel and kit meets stringent manufacturing criteria to ensure batch-to-batch reproducibility. The MILLIPLEX®
Human Fibrosis Panel 1 thus enables you to focus on the therapeutic potential of cytokines and the modulation of cytokine expression. Coupled with the Luminex®
platform in a magnetic bead format, you receive the advantage of ideal speed and sensitivity, allowing quantitative multiplex detection of dozens of analytes simultaneously, which can dramatically improve productivity.