The antibody datasheet indicates that the antibody was not tested against the different isoforms of IL-18. The capture antibody is a monoclonal mouse anti-Human IL-18 antibody, and the immunogen used is recombinant Human IL-18. However, it was not tested for cross-reactivity with the pro-form.
HIL18MAG-66K
MILLIPLEX® Human IL-18 Singleplex
Human IL-18 Singleplex Kit
Synonym(s):
Magnetic bead assay
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1 EA
$772.00
$772.00
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About This Item
NACRES:
NA.84
UNSPSC Code:
12161503
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Product Name
MILLIPLEX® Human IL-18 Singleplex, Human IL-18 Singleplex Kit
species reactivity
human
packaging
pkg of 1 ea
manufacturer/tradename
Milliplex®
input
serum
cell culture supernatant
detection method
fluorometric (Luminex® xMAP® technology)
shipped in
wet ice
storage temp.
2-8°C
Legal Information
Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Application
MILLIPLEX® Qualified assays undergo rigourous assay development, verification, and Quality Control testing to achieve optimal performance. Analyze IL-18 in human serum, plasma, and cell culture supernatants.
Analytes included: IL-18
Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.
Analytes included: IL-18
Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.
Disclaimer
For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
Features and Benefits
Facilitates Biomarker Discovery: Useful in studying diseases where IL-18 plays a role, such as autoimmune disorders, infections, and cancer.User-Friendly: The straightforward protocol makes it accessible even for labs with limited experience in cytokine assays.Multiplexing Flexibility: The IL-18 kit can be combined with other MILLIPLEX® kits, allowing for the simultaneous measurement of multiple cytokines and biomarkers in a single sample.
General description
Interleukin-18 (IL-18) is a pro-inflammatory cytokine that plays a crucial role in the immune response by promoting the activation and proliferation of T cells and natural killer (NK) cells. It is primarily produced by macrophages and dendritic cells and is involved in various physiological processes, including inflammation, infection, and autoimmune diseases. Elevated levels of IL-18 have been associated with several conditions, such as cardiovascular diseases, cancer, and chronic inflammatory disorders, making it an important biomarker for research and therapeutic targets.
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2
target_organs
Respiratory Tract
Storage Class
10 - Combustible liquids
wgk
WGK 3
Certificates of Analysis (COA)
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Are the antibodies in the human IL-18 singleplex kit (HIL18MAG-66K) specific to the mature form of IL-18, and is there information on their cross-reactivity with pro-IL18?
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