We conducted tests on 4 NHP samples and were able to detect EGF, Albumin, A1M, Clusterin, and Cystatin C in the samples. However, we were not able to detect OPN or NGAL, although the absence of signal could be attributed to low levels in the few samples tested. It's important to note that the kit has not been tested with NHP standards to determine the extent of reactivity.
HKI2MAG-99K
MILLIPLEX® Human Kidney Injury Panel
Configurable Human Kidney Toxicity 7-plex Panel 2
Synonym(s):
Human Kidney Toxicity Multiplex Assay, Luminex® Human Kidney Toxicity Assay, Millipore Human Kidney Toxicity Panel
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About This Item
UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000
To order a Milliplex® kit, please search for your analyte of interest.
Product Name
MILLIPLEX® Human Kidney Injury Panel,
Quality Segment
description
Configurable Human Kidney Toxicity 7-plex Panel 2
product line
Milliplex®
species reactivity
human
packaging
pkg of 1 ea
technique(s)
multiplexing: suitable
input
urine
assay range
accuracy: 95-109%, sensitivity: 0.015-5.359 ng/mL
(MinDC = 2SD), standard curve range: 0.01-10 ng/mL
(EGF), standard curve range: 0.02-20 ng/mL
(Lipocalin-2/ NGAL), standard curve range: 0.20-200 ng/mL
(Cystatin C), standard curve range: 0.59-600 ng/mL
(Osteopontin (OPN)), standard curve range: 0.98-1,000 ng/mL
(α-1-Microglobulin), standard curve range: 3.91-4,000 ng/mL
(Albumin), standard curve range: 4.88-5,000 ng/mL
(Clusterin), inter-assay cv: <20%
intra-assay cv: <10%
detection method
fluorometric (Luminex® xMAP® technology)
shipped in
wet ice
storage temp.
2-8°C
General description
Clusterin, Cystatin C, Lipocalin-2/NGAL, Osteopontin, and Uromodulin are key biomarkers associated with kidney injury, inflammation, and tubular function. These analytes provide insights into early renal damage, immune response, and epithelial integrity, making them valuable for studying acute kidney injury, chronic kidney disease, and nephrotoxicity. Their combined measurement supports comprehensive assessment of renal health and disease progression.
Application
MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 7 analytes in human urine samples.
Analytes included: α-1-Microglobulin, Albumin, Clusterin, Cystatin C, EGF, Lipocalin-2/NGAL, Osteopontin (OPN)
Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.
Analytes included: α-1-Microglobulin, Albumin, Clusterin, Cystatin C, EGF, Lipocalin-2/NGAL, Osteopontin (OPN)
Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.
Features and Benefits
Features:
- 7-plex multiplexing allows simultaneous quantification of seven kidney injury biomarkers in human urine samples
- Includes α-1-Microglobulin, Albumin, Clusterin, Cystatin C, EGF, Lipocalin-2/NGAL, and Osteopontin (OPN)
- Magnetic bead-based format improves assay precision and simplifies washing steps
- Utilizes Luminex® xMAP® technology for high-throughput analysis with minimal sample volume
- Validated for use with human urine samples
- Compatible with both manual and automated workflows
- Enables early detection of renal injury before traditional markers show abnormalities
- Provides comprehensive coverage of biomarkers involved in nephrotoxicity and renal dysfunction
- Conserves valuable samples by measuring multiple analytes in a single assay
- Accelerates research in drug development, toxicology, and translational studies
- Delivers high sensitivity and specificity with minimal cross-reactivity
Legal Information
Luminex is a registered trademark of Luminex Corporation
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Disclaimer
For research use only. Not for use in diagnostic procedures.
Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
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This Item | |||
|---|---|---|---|
| description - | description - | description - | description - |
| species reactivity human | species reactivity human | species reactivity human | species reactivity human |
| assay range accuracy: 95-109%, standard curve range: 0.01-10 ng/mL | assay range accuracy: 73-117%, sensitivity: 0.010-6.473 ng/mL | assay range accuracy: 103-133%, intra-assay cv: <10, sensitivity: 0.10-3.42 ng/mL | assay range accuracy: 63-118%, intra-assay cv: <10, sensitivity: 0.01-0.71 ng/mL |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| technique(s) multiplexing: suitable | technique(s) multiplexing: suitable | technique(s) multiplexing: suitable | technique(s) multiplexing: suitable |
| shipped in wet ice | shipped in wet ice | shipped in wet ice | shipped in wet ice |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
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Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2
target_organs
Respiratory Tract
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
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Do any of the analytes available in the Milliplex Human Kidney Injury Panel 2 exhibit cross-reactivity with NHP samples?
1 answer-
Helpful?
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How should urine samples for use in the Milliplex Kidney Injury Panels be stored? Is it better to store them at 4°C if they will be used in a few days or go through a freeze/thaw cycle?
1 answer-
The samples remain stable for up to one day at 4°C, but for longer-term storage, it is preferable to store them at -80°C. Additionally, the samples are stable for up to one freeze/thaw cycle. If more freeze/thaw cycles are required, it is best to aliquot the samples.
Helpful?
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