HTMP1MAG-54K

MILLIPLEX^® Human TIMP Panel

Configurable Human TIMP 2-Plex Panel 1 for serum/plasma samples

• UNSPSC Code: 12161503
• NACRES: NA.84
• eCl@ss: 32161000

Properties

• Product Name: MILLIPLEX^® Human TIMP Panel,
• Quality Segment: 200
• description: Configurable Human TIMP 2-Plex Panel 1 for serum/plasma samples
• product line: Milliplex^®
• species reactivity: human
• packaging: pkg of 1 ea
• assay range: accuracy: 92-101%, standard curve range: 20-20,000 pg/mL; (TIMP-1), standard curve range: 49-50,000 pg/mL; (TIMP-2)
• technique(s): multiplexing: suitable
• input: serum; plasma
• detection method: fluorometric (Luminex^® xMAP^® technology)
• shipped in: wet ice
• storage temp.: 2-8°C

Description

General description

Tissue Inhibitors of Metalloproteinases (TIMPs) comprise a family of four inhibitors known as TIMP-1, TIMP-2, TIMP-3, and TIMP-4. Each member of the TIMP family has its own distinct profile of metalloproteinase inhibition. The matrix metalloproteinases (MMPs) are a family of zinc proteases involved in the breakdown of extracellular matrix (ECM) in normal physiological processes, such as embryonic development, tissue and bone remodeling, wound healing, tissue morphogenesis, angiogenesis, and tumor metastasis. MMPs are also known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), cell proliferation, differentiation, and chemokine in/activation. The normal function of MMPs must be precisely regulated by their endogenous protein inhibitors, TIMPs . TIMPs inhibit MMPs by forming 1:1, non-covalent complexes with MMPs, thereby blocking access of substrates to the MMP catalytic site. Except for inhibition of active MMPs, TIMPs also exhibit several other biochemical and physiological/biological functions such as proMMP activation, cell growth promotion, matrix binding, inhibition of angiogenesis and the induction of apoptosis. Disruption of the MMP/TIMP balance can result in serious diseases such as arthritis, cardiovascular disorders, tumor growth and metastasis.

Application

MILLIPLEX^® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 2 analytes in human serum and plasma.

Analytes included: TIMP-1, TIMP-2

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Features and Benefits

• Targets Key TIMPs: Enables simultaneous quantification of multiple TIMP biomarkers (e.g., TIMP-1, TIMP-2) in a single sample, saving time and resources.

• High Sensitivity and Wide Dynamic Range: Detects TIMP-1 from 20–20,000 pg/mL and TIMP-2 from 49–50,000 pg/mL, ensuring accurate detection across physiological and pathological levels.

• Supports MMP/TIMP Pathway Research: Ideal for studying extracellular matrix remodeling, angiogenesis, apoptosis, and tumor metastasis.

• Optimized for Serum and Plasma Samples: Specifically designed for human serum and plasma, ensuring high compatibility and reliable performance in clinical research.

• Reliable Reproducibility: Intra- and inter-assay CVs < 10%, ensuring consistent results across experiments.

Legal Information

Luminex is a registered trademark of Luminex Corporation

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 3
• pictograms: GHS08,GHS05,GHS07,GHS09
• signalword: Danger
• hcodes: H302 + H312 + H332,H315,H317,H318,H373,H411
• pcodes: P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P314
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2
• target_organs: Respiratory Tract