IL038
Interleukin-1β Protein, Recombinant human
The recombinant human Interleukin-1beta protein (or IL-1beta protein) is a potent immuno-modulator which mediates a wide range of immune & inflammatory responses including the activation of B & T-cells.
Synonym(s):
IL-1beta
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IL038
$430.00
$430.00
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About This Item
UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.75
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biological source
human
Quality Level
assay
>98% (SDS-PAGE and HPLC)
specific activity
>1 x 10e9 U/mg
manufacturer/tradename
Chemicon®
technique(s)
cell culture | mammalian: suitable
impurities
<0.1 ng/μg endotoxin (of human IL-1beta; 1EU/μg)
input
sample type hematopoietic stem cell(s)
NCBI accession no.
UniProt accession no.
shipped in
dry ice
1 of 4
This Item | H6291 | I5271 | I2393 |
|---|---|---|---|
| assay >98% (SDS-PAGE and HPLC) | assay ≥95% (SDS-PAGE) | assay ≥97% (SDS-PAGE) | assay ≥98% (SDS-PAGE and HPLC) |
| biological source human | biological source human | biological source mouse | biological source rat |
| technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable |
| shipped in dry ice | shipped in - | shipped in - | shipped in - |
| specific activity >1 x 10e9 U/mg | specific activity - | specific activity - | specific activity - |
| impurities <0.1 ng/μg endotoxin (of human IL-1beta; 1EU/μg) | impurities <1 EU/μg | impurities ≤0.1ng/mg | impurities <0.1 EU/μg |
General description
Interleukin-1beta (IL-1beta) is a potent immuno-modulator which mediates a wide range of immune and inflammatory responses including the activation of B and T-cells. Human IL-1beta is a 17.3 kDa protein containing 153 amino acid residues.
Application
For most in vitro applications, human IL-1beta is fully biological activity in the concentration range of 0.1 to 10.0 ng/mL. Responding cells are (partial list): Leukocytes.
Physical form
Sterile filtered and lyophilized from 10 mM Tris, pH 8.2 with no preservatives.
Preparation Note
The lyophilized human IL-1beta, though stable at room temperature, is best stored desiccated at -20°C. After a quick spin, reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can be diluted into other buffered solutions. Reconstituted human IL-1beta should be stored in undiluted aliquots at -20°C for up to six months.
Analysis Note
Specific Activity: Chemicon′s human IL-1beta is fully biologically active when compared to standards.The ED(50) as determined by the dose-dependent stimulation of the proliferation of murine D10S cells is <0.001 ng/mL
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Byounghoon Brian Hwang et al.
Communications biology, 3, 8-8 (2020-01-08)
Monitoring cellular signaling events can help better understand cell behavior in health and disease. Traditional immunoassays to study proteins involved in signaling can be tedious, require multiple steps, and are not easily adaptable to high throughput screening (HTS). Here, we
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Defois, et al.
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Toxoplasma gondii is a common opportunistic protozoan pathogen that can parasitize the karyocytes of humans and virtually all other warm-blooded animals. In the host's innate immune response to T. gondii infection, inflammasomes can mediate the maturation of pro-IL-1β and pro-IL-18
Rojo A Ratsimandresy et al.
Nature communications, 8, 15556-15556 (2017-06-06)
Inflammasomes are protein platforms linking recognition of microbe, pathogen-associated and damage-associated molecular patterns by cytosolic sensory proteins to caspase-1 activation. Caspase-1 promotes pyroptotic cell death and the maturation and secretion of interleukin (IL)-1β and IL-18, which trigger inflammatory responses to
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