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MAB1578

Anti-Muscarinic Acetylcholine Receptor m4 Antibody, clone 18C7.2

clone 18C7.2, Chemicon®, from mouse

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MAB1578

$506.00

$506.00

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

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biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

18C7.2, monoclonal

purified by

using Protein A

species reactivity

monkey

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_000741.2

UniProt accession no.

P08173

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

rhesus monkey ... Chrm4(574195)

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Anti-Muscarinic Acetylcholine Receptor m4 Antibody, clone 18C7.2 clone 18C7.2, Chemicon®, from mouse

Sigma-Aldrich

MAB1578

Anti-Muscarinic Acetylcholine Receptor m4 Antibody, clone 18C7.2

Anti-Muscarinic Acetylcholine Receptor m4 Antibody, clone 17F10.2 purified antibody, clone 17F10.2, Chemicon®

Sigma-Aldrich

MAB1576

Anti-Muscarinic Acetylcholine Receptor m4 Antibody, clone 17F10.2

Anti-Muscarinic Acetylcholine Receptor m1 Antibody Chemicon®, from rabbit

Sigma-Aldrich

AB5164

Anti-Muscarinic Acetylcholine Receptor m1 Antibody

Anti-Integrin β6 Antibody, clone CSβ6, azide free clone CSbeta6, Chemicon®, from mouse

Sigma-Aldrich

MAB2076Z

Anti-Integrin β6 Antibody, clone CSβ6, azide free

biological source

mouse

biological source

mouse

biological source

rabbit

biological source

mouse

species reactivity

monkey

species reactivity

mouse, monkey, rat

species reactivity

rat, mouse

species reactivity

human, monkey, rat, rabbit

clone

18C7.2, monoclonal

clone

17F10.2, monoclonal

clone

polyclonal

clone

CSbeta6, monoclonal

Gene Information

rhesus monkey ... Chrm4(574195)

Gene Information

mouse ... Chrm4(12672)
rat ... Chrm4(25111)
rhesus monkey ... Chrm4(574195)

Gene Information

human ... CHRM1(1128)

Gene Information

human ... ITGB6(3694)
mouse ... Itgb6(16420)
rat ... Itgb6(311061)
rhesus monkey ... Itgb6(700454)

antibody form

purified antibody

antibody form

purified antibody

antibody form

affinity purified immunoglobulin

antibody form

purified antibody

UniProt accession no.

P08173

UniProt accession no.

P08173

UniProt accession no.

P11229

UniProt accession no.

P18564

Immunogen

m4 receptor i3 loop (human), fused to GST

Application

Anti-Muscarinic Acetylcholine Receptor m4 Antibody, clone 18C7.2 detects level of Muscarinic Acetylcholine Receptor m4 & has been published & validated for use in IH, IP & WB.
Immunohistochemistry (monkey)

Western blot (transfected CHO cell lines)

Immunoprecipitation (rat and monkey)

Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors

Biochem/physiol Actions

m4 muscarinic acetylcholine receptor. No reactivity with the other subtypes.

Physical form

Liquid in 0.02M Phosphate buffer, 0.25 M NaCl with 0.1% sodium azide.

Preparation Note

Maintain at 2-8°C in undiluted aliquots for up to 6 months.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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G Q Li et al.
Neuroscience, 146(1), 384-402 (2007-03-30)
Muscarinic acetylcholine receptors (mAChRs) are widely expressed in the CNS and peripheral nervous system and play an important role in modulating the cell activity and function. We have shown that the cholinergic agonist carbachol reduces the pigeon's inwardly rectifying potassium
Deborah Bauer et al.
Schizophrenia research, 117(1), 92-98 (2009-09-01)
The excitatory amino acid transporters (EAATs) are a family of molecules that are essential for regulation of synaptic glutamate levels. The EAATs may also be regulated by N-glycosylation, a posttranslational modification that is critical for many cellular functions including localization
Christianne E Strang et al.
Investigative ophthalmology & visual science, 51(5), 2778-2789 (2010-01-01)
The activation and blockade of muscarinic acetylcholine receptors (mAChRs) affects retinal ganglion cell light responses and firing rates. This study was undertaken to identify the full complement of mAChRs expressed in the rabbit retina and to assess mAChR distribution and
Judith Molina et al.
Diabetes, 63(8), 2714-2726 (2014-03-25)
Acetylcholine regulates hormone secretion from the pancreatic islet and is thus crucial for glucose homeostasis. Little is known, however, about acetylcholine (cholinergic) signaling in the human islet. We recently reported that in the human islet, acetylcholine is primarily a paracrine
Jivan Khlghatyan et al.
Cerebral cortex (New York, N.Y. : 1991), 29(9), 3813-3827 (2018-10-09)
Cortical D2 dopamine receptor (Drd2) have mostly been examined in the context of cognitive function regulation and neurotransmission modulation of medial prefrontal cortex by principal neurons and parvalbumin positive, fast-spiking, interneurons in schizophrenia. Early studies suggested the presence of D2

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