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MAB1914P

Sigma-Aldrich

Anti-Laminin gamma 1 Antibody, clone A5

clone A5, Chemicon®, from rat

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Synonym(s):
LAMC1
eCl@ss:
32160702
NACRES:
NA.41

biological source

rat

Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

A5, monoclonal

species reactivity

mouse, human

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable (paraffin)

isotype

IgG2aκ

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... LAMC1(3915)

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This Item
WH0003915M1SAB1404015MAB1920
biological source

rat

biological source

mouse

biological source

mouse

biological source

mouse

Gene Information

human ... LAMC1(3915)

Gene Information

human ... LAMC1(3915)

Gene Information

human ... LAMC1(3915)

Gene Information

human ... LAMC1(3915)

clone

A5, monoclonal

clone

2E6-B4, monoclonal

clone

M1, monoclonal

clone

2E8, monoclonal

species reactivity

mouse, human

species reactivity

human

species reactivity

human

species reactivity

rat, human

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

100

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General description

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Variations in the expression of laminins have been observed in embryogenesis, organogenesis, post traumatic healing and cancer. Laminins have been provoked by the discovery of their ability to promote neurite regeneration. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively). The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly.

Immunogen

Basement membrane protein preparation from mouse EHS tumor.

Application

Detect Laminin gamma 1 using this Anti-Laminin gamma 1 Antibody, clone A5 validated for use in IH(P).
Research Sub Category
ECM Proteins

Adhesion (CAMs)

Target description

177 kDa

Physical form

Format: Purified
Purified rat immunoglobulin in buffer containing 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.

Analysis Note

Control
Tubular carcinoma of the colon and fibroneuroma

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Henry J Bonilla et al.
GeroScience, 42(6), 1431-1443 (2020-09-19)
Analysis of skeletal muscle mass and composition is essential for studying the biology of age-related sarcopenia, loss of muscle mass, and function. Muscle immunohistochemistry (IHC) allows for simultaneous visualization of morphological characteristics and determination of fiber type composition. The information
Raphael Reuten et al.
Nature materials, 20(6), 892-903 (2021-01-27)
The basement membrane (BM) is a special type of extracellular matrix and presents the major barrier cancer cells have to overcome multiple times to form metastases. Here we show that BM stiffness is a major determinant of metastases formation in
Fenny Wiradjaja et al.
Disease models & mechanisms, 6(6), 1426-1433 (2013-09-21)
Fras1-related extracellular matrix protein 1 (FREM1) is required for epidermal adhesion during embryogenesis, and mice lacking the gene develop fetal skin blisters and a range of other developmental defects. Mutations in members of the FRAS/FREM gene family cause diseases of
Alejandro E Mayorca-Guiliani et al.
Nature protocols, 14(12), 3395-3425 (2019-11-11)
The extracellular matrix (ECM) is a major regulator of homeostasis and disease, yet the 3D structure of the ECM remains poorly understood because of limitations in ECM visualization. We recently developed an ECM-specialized method termed in situ decellularization of tissues
Daniel Öhlund et al.
BMC cancer, 13, 154-154 (2013-03-28)
Pancreatic cancer shows a highly aggressive and infiltrative growth pattern and is characterized by an abundant tumor stroma known to interact with the cancer cells, and to influence tumor growth and drug resistance. Cancer cells actively take part in the

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