MAB2078Z

Anti-Integrin α9β1 Antibody, clone Y9A2, azide free

Name: Anti-Integrin α9β1 Antibody, clone Y9A2, azide free
Brand: MM
Price: 534 USD

clone Y9A2, Chemicon^®, from mouse

Synonym(s):

MAB2078

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100 μG

$534.00

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

Y9A2, monoclonal

Application:

flow cytometry
immunoprecipitation (IP)

Species reactivity:

human, guinea pig

Citations:

Technique(s):

flow cytometry: suitable
immunoprecipitation (IP): suitable

Uniprot accession no.:

Q13797

Key Documents

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Product Name

Anti-Integrin α9β1 Antibody, clone Y9A2, azide free, clone Y9A2, Chemicon^®, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

Y9A2, monoclonal

species reactivity

human, guinea pig

should not react with

rat

manufacturer/tradename

Chemicon^®

technique(s)

flow cytometry: suitable
immunoprecipitation (IP): suitable

isotype

IgG1

suitability

not suitable for Western blot
not suitable for immunohistochemistry

NCBI accession no.

NM_002207.2

UniProt accession no.

Q13797

shipped in

wet ice

target post-translational modification

unmodified

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This Item	MAB1998Z	MAB1953Z	MAB2075Z
Sigma-Aldrich MAB2078Z Anti-Integrin α9β1 Antibody, clone Y9A2, azide free	Sigma-Aldrich MAB1998Z Anti-Integrin α2β1 Antibody, clone BHA2.1, azide free	Sigma-Aldrich MAB1953Z Anti-Integrin αV Antibody, clone P3G8, azide free	Sigma-Aldrich MAB2075Z Anti-Integrin β6 Antibody, clone R6G9, azide free
biological source mouse	biological source mouse	biological source mouse	biological source mouse
Gene Information human ... ITGA9(3680)	Gene Information human ... ITGA2(3673)	Gene Information human ... ITGAV(3685)	Gene Information human ... ITGB6(3694)
antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified antibody	antibody form purified antibody
clone Y9A2, monoclonal	clone BHA2.1, monoclonal	clone P3G8, monoclonal	clone R6G9, monoclonal
species reactivity human, guinea pig	species reactivity human, pig	species reactivity human	species reactivity human
technique(s) flow cytometry: suitable, immunoprecipitation (IP): suitable	technique(s) flow cytometry: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable	technique(s) ELISA: suitable, flow cytometry: suitable, immunocytochemistry: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable	technique(s) flow cytometry: suitable, immunoprecipitation (IP): suitable

Analysis Note

Control
Integrin alpha9beta1 positive tissues include basal keratinocytes, hepatocytes, muscle (smooth and skeletal), and airway epithelium.

Application

Detect Integrin α9β1 using this Anti-Integrin α9β1 Antibody, clone Y9A2, azide free validated for use in FC & IP.

Immunoprecipitation

FACS Analysis

Function blocking: 100% inhibition of alpha9beta1-mediated adhesion to the third fibronectin type III repeat in tenascin at <10 μg/mL.

Not effective for immunohistochemistry, immunocytochemistry or western blot.

Optimal working dilutions must be determined by end user.

Research Category
Cell Structure

Research Sub Category
Integrins

Biochem/physiol Actions

Reactive with human and guinea pig alpha9beta1.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

Murine L cells transfected with human alpha9.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified

Protein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with no preservatives.

Protein A purified

Preparation Note

Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Isolation and characterisation of lymphatic endothelial cells from lung tissues affected by lymphangioleiomyomatosis.

Koichi Nishino et al.

Scientific reports, 11(1), 8406-8406 (2021-04-18)

Lymphangioleiomyomatosis (LAM) is a rare pulmonary disease characterised by the proliferation of smooth muscle-like cells (LAM cells), and an abundance of lymphatic vessels in LAM lesions. Studies reported that vascular endothelial growth factor-D (VEGF-D) secreted by LAM cells contributes to

Suppression of integrin α3β1 by α9β1 in the epidermis controls the paracrine resolution of wound angiogenesis.

Whitney M Longmate et al.

The Journal of cell biology, 216(5), 1473-1488 (2017-04-19)

Development of wound therapies is hindered by poor understanding of combinatorial integrin function in the epidermis. In this study, we generated mice with epidermis-specific deletion of α3β1, α9β1, or both integrins as well as keratinocyte lines expressing these integrin combinations.

ADAM12 and alpha9beta1 integrin are instrumental in human myogenic cell differentiation.

Peggy Lafuste et al.

Molecular biology of the cell, 16(2), 861-870 (2004-12-03)

Knowledge on molecular systems involved in myogenic precursor cell (mpc) fusion into myotubes is fragmentary. Previous studies have implicated the a disintegrin and metalloproteinase (ADAM) family in most mammalian cell fusion processes. ADAM12 is likely involved in fusion of murine

Cellular Adhesion Is a Controlling Factor in Neutrophil Extracellular Trap Formation Induced by Anti-Neutrophil Cytoplasmic Antibodies.

Patrick M Lelliott et al.

ImmunoHorizons, 6(2), 170-183 (2022-02-24)

Anti-neutrophil cytoplasmic Ab (ANCA)-associated vasculitis (AAV) is a life-threatening condition characterized by improper activation of neutrophils and the release of neutrophil extracellular traps (NETs) in small vessels. This study aimed to explain the role of NETs in AAV pathogenesis by

Migration-promoting role of VEGF-C and VEGF-C binding receptors in human breast cancer cells.

A V Timoshenko et al.

British journal of cancer, 97(8), 1090-1098 (2007-10-04)

Vascular endothelial growth factor C (VEGF-C) is a lymphangiogenic factor over-expressed in highly metastatic, cyclooxygenase (COX)-2 expressing breast cancer cells. We tested the hypothesis that tumour-derived VEGF-C may play an autocrine role in metastasis by promoting cellular motility through one

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