MAB2511

Anti-VCAM-1 Antibody, clone P8B1

Name: Anti-VCAM-1 Antibody, clone P8B1
Brand: MM

clone P8B1, Chemicon^®, from mouse

Synonym(s):

CD106

Slide 1 of 1

Select a Size

Pricing and availability is not currently available.

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

P8B1, monoclonal

Application:

—

Citations:

Key Documents

View All Documentation

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

P8B1, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon^®

isotype

IgG2b

NCBI accession no.

NM_001078.2, NM_080682.1

UniProt accession no.

P19320

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... L1CAM(3897), VCAM1(7412)

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item	MAB2511Z	CBL1300	MAB2627
Sigma-Aldrich MAB2511 Anti-VCAM-1 Antibody, clone P8B1	Sigma-Aldrich MAB2511Z Anti-VCAM-1 Antibody, clone P8B1, Azide Free	Sigma-Aldrich CBL1300 Anti-VCAM-1 Antibody, clone M/K	Sigma-Aldrich MAB2627 Anti-VCAM-1 (CD106) Antibody, clone 6C7.1
species reactivity human	species reactivity human	species reactivity mouse	species reactivity mouse
antibody form purified immunoglobulin	antibody form purified antibody	antibody form purified antibody	antibody form purified immunoglobulin
clone P8B1, monoclonal	clone P8B1, monoclonal	clone M/K - 2, monoclonal	clone 6C7.1, monoclonal
biological source mouse	biological source mouse	biological source rat	biological source rat
Gene Information human ... L1CAM(3897), VCAM1(7412)	Gene Information human ... L1CAM(3897), VCAM1(7412)	Gene Information human ... L1CAM(3897), VCAM1(7412)	Gene Information human ... L1CAM(3897), VCAM1(7412)
shipped in wet ice	shipped in dry ice	shipped in wet ice	shipped in dry ice

Application

Anti-VCAM-1 Antibody, clone P8B1 detects level of VCAM-1 & has been published & validated.

Function blocking

Optimal working dilutions must be determined by end user.

Biochem/physiol Actions

MAB2511 recognizes the human VCAM-1 molecule. The antibody inhibits VLA-4 (integrin alpha4beta1) binding and recognizes a different epitope than that which is recognized by MAB2144 (P3C4 clone).

Physical form

Format: Purified

Purified immunoglobulin. Liquid in 0.2 M phosphate buffer to 0.25 M NaCl, pH 7.6 with 0.1% sodium azide. Caution: Sodium azide is toxic. See online MSDS.

Preparation Note

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.

During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container′s cap.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Not finding the right product?

Try our Product Selector Tool.

Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Significant Differences in Antigen-Induced Transendothelial Migration of Human CD8 and CD4 T Effector Memory Cells.

Thomas D Manes et al.

Arteriosclerosis, thrombosis, and vascular biology, 36(9), 1910-1918 (2016-07-23)

Circulating human T effector memory cell (TEM) recognition of nonself MHC (major histocompatibility complex) molecules on allograft endothelial cells can initiate graft rejection despite elimination of professional antigen-presenting cells necessary for naive T-cell activation. Our previous studies of CD4 TEM

Endothelial transmigration hotspots limit vascular leakage through heterogeneous expression of ICAM-1.

Max L B Grönloh et al.

EMBO reports, 24(1), e55483-e55483 (2022-11-17)

Upon inflammation, leukocytes leave the circulation by crossing the endothelial monolayer at specific transmigration "hotspot" regions. Although these regions support leukocyte transmigration, their functionality is not clear. We found that endothelial hotspots function to limit vascular leakage during transmigration events.

Integrin alpha4beta1-VCAM-1-mediated adhesion between endothelial and mural cells is required for blood vessel maturation.

Barbara Garmy-Susini et al.

The Journal of clinical investigation, 115(6), 1542-1551 (2005-05-20)

Neovascularization depends on vascular cell proliferation and on the stabilization of vessels by association of vascular smooth muscle-like pericytes with ECs. Here we show that integrin alpha4beta1 (VLA-4) and VCAM-1 promote close intercellular adhesion between ECs and pericytes and that

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service