All Photos(5)




Anti-Glutamine Synthetase Antibody, clone GS-6

clone GS-6, Chemicon®, from mouse


biological source


Quality Level

antibody form

purified immunoglobulin


GS-6, monoclonal

species reactivity

human, rat, mouse, sheep




ELISA: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable



NCBI accession no.

UniProt accession no.

shipped in

dry ice

Gene Information

human ... GLUL(2752)

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified antibody

antibody form

purified immunoglobulin


GS-6, monoclonal


1G10.2, monoclonal


9G1.2, monoclonal


TS106, monoclonal

species reactivity

human, rat, mouse, sheep

species reactivity

human, mouse, rat

species reactivity


species reactivity

human, mouse










ELISA: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, western blot: suitable


immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, western blot: suitable


immunohistochemistry: suitable (paraffin), western blot: suitable


ELISA: suitable, flow cytometry: suitable, immunofluorescence: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, immunoprecipitation (IP): suitable, western blot: suitable

General description

Glutamine Synthetase catalyzes the conversion of ammonia and glutamate to glutamine. It is found in astrocytes as an octamer of identical 45 kDa subunits. The function of Glutamine Synthetase is the detoxification of brain ammonia. It also has an important role in the metabolic regulation of neurotransmitter glutamate. Because of the multiple functions and importance of Glutamine Synthetase in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of Glutamine Synthetase is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer′s disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation. The level of expression of Glutamine Synthetase is increased during ischemia in vivo or hypoxia in culture.


Reacts strongly with a single band on Western blots of sheep brain and rat brain. Glutamine synthetase, an enzyme that catalyzes the amination of glutamic acid to form glutamine, is found in mammals as an octamer of eight identical 45 kDa subunits. Glutamine synthetase activity has been shown to be a useful marker of astrocytes and an important differentiation feature in retina. Glutamine synthetase is also considered to be a key enzyme in the recycling of the neurotransmitter glutamate.


Glutamine synthetase purified from sheep brain.


Detect Glutamine Synthetase using this Anti-Glutamine Synthetase Antibody, clone GS-6 validated for use in ELISA, IH, IH(P) & WB with more than 45 product citations.
Research Category
Research Sub Category
Neurofilament & Neuron Metabolism
Western blot: 1:1,000-1:5,000

Immunohistochemistry on rat brain


Optimal working dilutions must be determined by end user.

Target description

45 kDa

Physical form

Format: Purified
Protein A purified
Purified immunoglobulin. Liquid in buffer containing 50% glycerol, BSA and 0.09% sodium azide.

Storage and Stability

Stable for 1 year at -20ºC in undiluted aliquots from date of receipt.

Analysis Note

Rat brain tissue, rat brain cytosolic fraction extract

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (Example: T1503).


Product Number
Pack Size/Quantity

Additional examples:





enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Markel Olabarria et al.
Molecular neurodegeneration, 6, 55-55 (2011-08-02)
Astrocytes are fundamental for brain homeostasis and the progression and outcome of many neuropathologies including Alzheimer's disease (AD). In the triple transgenic mouse model of AD (3xTg-AD) generalised hippocampal astroglia atrophy precedes a restricted and specific β-amyloid (Aβ) plaque-related astrogliosis.
Takahiko Matsuda et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(1), 16-22 (2003-11-07)
The large number of candidate genes made available by comprehensive genome analysis requires that relatively rapid techniques for the study of function be developed. Here, we report a rapid and convenient electroporation method for both gain- and loss-of-function studies in
Effects of retinal glial cells on isolated rat retinal ganglion cells.
K Kashiwagi, Y Iizuka, M Araie, Y Suzuki, S Tsukahara
Investigative Ophthalmology & Visual Science null
Redistribution of astrocytic glutamine synthetase in the hippocampus of chronic epileptic rats.
Papageorgiou IE, Gabriel S, Fetani AF, Kann O, Heinemann U.
Glia null
N Hakuba et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 20(23), 8750-8753 (2000-01-11)
Acoustic overstimulation is one of the major causes of hearing loss. Glutamate is the most likely candidate neurotransmitter for afferent synapses in the peripheral auditory system, so it was proposed that glutamate excitotoxicity may be involved in noise trauma. However

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service