MAB3502-I

Sigma-Aldrich

Anti-Angiotensin Converting Enzyme Antibody, clone 2E2

culture supernatant, clone 2E2, from mouse

Synonym(s):
Angiotensin-converting enzyme, ACE, Dipeptidyl carboxypeptidase I, Kininase II, CD143
eCl@ss:
32160702
NACRES:
NA.41

Quality Level

biological source

mouse

antibody form

culture supernatant

antibody product type

primary antibodies

clone

2E2, monoclonal

species reactivity

rat

species reactivity (predicted by homology)

human (immunogen homology)

application(s)

western blot: suitable

isotype

IgG1

NCBI accession no.

UniProt accession no.

shipped in

wet ice

General description

Angiotensin-converting enzyme (ACE) is a zinc-metallopeptidase belonging to the peptidase M2 family. It catalyzes the conversion of angiotensin I to angiotensin II and the degradation of bradykinin, which increases the vasoconstrictive effects of angiotensin. The Angiotensin-converting enzyme plays an important role in maintaining cardiac function and vascular tone. It is highly expressed in the heart, lung, kidney, gastrointestinal system, and prostate. Defects in the Angiotensin-converting may contribute cardiac disease; and renal tubular dysgenesis, a condition characterized by persistent fetal anuria and perinatal death.

Immunogen

Human Angiotensin Converting Enzyme.

Application

Anti-Angiotensin Converting Enzyme Antibody, clone 2E2.

Quality

Evaluated by Western Blot in rat Angiotensin Converting Enzyme.

Western Blot Analysis: A 1:2,000 dilution of this antibody detected rat Angiotensin Converting Enzyme in WB.

Target description

~180 kDa observed. The calculated molecular weight is 150 kDa; however, this protein is known to be glycolsylated.

Linkage

Replaces: MAB3502

Physical form

Mouse monoclonal IgG1 cultured supernatant without preservatives.

Analysis Note

Control
Rat Angiotensin Converting Enzyme

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