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Anti-53BP1 Antibody, clone BP18

Name: Anti-53BP1 Antibody, clone BP18
Brand: MM
Price: 490 USD

ascites fluid, clone BP18, Chemicon^®

Synonym(s):

p53 Binding Protein 1

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Pack Size	SKU	Availability	Price
100 μg		Check Cart for Availability	$490.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

BP18, monoclonal

Application:

IF, WB

Citations:

$490.00

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Properties

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

BP18, monoclonal

species reactivity

mouse, human

manufacturer/tradename

Chemicon^®

technique(s)

immunofluorescence: suitable, western blot: suitable

isotype

IgM

NCBI accession no.

NM_005657.1

UniProt accession no.

Q12888

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... TP53BP1(7158)

Description

Immunogen

Recombinant human 53BP1 proteins.

Application

Anti-53BP1 Antibody, clone BP18 is a Mouse Monoclonal Antibody for detection of 53BP1 also known as p53 Binding Protein 1 & has been validated in IF & WB.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Cell Cycle, DNA Replication & Repair

Western blot. Recognizes a protein of >250 kD. Suggested dilution buffer is TBST. Suggested blocking buffer is 5% non-fat dry milk.

Immunocytochemistry

Immunoprecipitation. Expected size in immunoblot is >250 kD. Suggested lysis buffer is NETN. Suggested capture agent is Protein A + rabbit anti-mouse linker antibody.

Optimal working dilutions must be determined by the end user.

Biochem/physiol Actions

53BP1

Physical form

Ascites. Liquid.

Preparation Note

Maintain at -20°C in undiluted aliquots up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Show Differences

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This Item	SAB4503017	SAB4504071	WH0007158M1
Sigma-Aldrich MAB3804 Anti-53BP1 Antibody, clone BP18	Sigma-Aldrich SAB4503017 Anti-53BP1 antibody produced in rabbit	Sigma-Aldrich SAB4504071 Anti-phospho-53BP1 (pSer⁶) antibody produced in rabbit	Sigma-Aldrich WH0007158M1 Monoclonal Anti-TP53BP1 antibody produced in mouse
antibody form ascites fluid	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form purified immunoglobulin
biological source mouse	biological source rabbit	biological source rabbit	biological source mouse
species reactivity mouse, human	species reactivity mouse, human	species reactivity human, mouse, rat	species reactivity human
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Gene Information human ... TP53BP1(7158)	Gene Information human ... TP53BP1(7158)	Gene Information human ... TP53BP1(7158)	Gene Information human ... TP53BP1(7158)
clone BP18, monoclonal	clone polyclonal	clone polyclonal	clone 1B9, monoclonal

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Human skin aging is associated with increased expression of the histone variant H2A.J in the epidermis.

Claudia E Rübe et al.

NPJ aging and mechanisms of disease, 7(1), 7-7 (2021-04-03)

Cellular senescence is an irreversible growth arrest that occurs as a result of damaging stimuli, including DNA damage and/or telomere shortening. Here, we investigate histone variant H2A.J as a new biomarker to detect senescent cells during human skin aging. Skin

ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication.

Dejie Wang et al.

Science advances, 7(25) (2021-06-20)

53BP1 activates nonhomologous end joining (NHEJ) and inhibits homologous recombination (HR) repair of DNA double-strand breaks (DSBs). Dissociation of 53BP1 from DSBs and consequent activation of HR, a less error-prone pathway than NHEJ, helps maintain genome integrity during DNA replication;

TLK1-mediated RAD54 phosphorylation spatio-temporally regulates Homologous Recombination Repair.

Ishita Ghosh et al.

Nucleic acids research, 51(16), 8643-8662 (2023-07-13)

Environmental agents like ionizing radiation (IR) and chemotherapeutic drugs can cause severe damage to the DNA, often in the form of double-strand breaks (DSBs). Remaining unrepaired, DSBs can lead to chromosomal rearrangements, and cell death. One major error-free pathway to

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Global Trade Item Number

SKU	GTIN
MAB3804	04053252466168

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