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MAB5432

Sigma-Aldrich

Anti-CREB Antibody

Chemicon®, from mouse

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Synonym(s):
cAMP-response Element Binding Protein
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

monoclonal

species reactivity

human, mouse, rat

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... CREB1(1385)

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This Item
AB3006ABE553AV31264
Sigma-Aldrich

MAB5432

Anti-CREB Antibody

Sigma-Aldrich

AB3006

Anti-CREB Antibody

Anti-CREB-1 Antibody from rabbit, purified by affinity chromatography

ABE553

Anti-CREB-1 Antibody

clone

monoclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

species reactivity

human, mouse, rat

species reactivity

human, mouse, rat

species reactivity

human, rat

species reactivity

mouse, horse, rabbit, rat, dog, human

Gene Information

human ... CREB1(1385)

Gene Information

human ... CREB1(1385)

Gene Information

human ... CREB1(1385)

Gene Information

human ... CREB1(1385)

biological source

mouse

biological source

rabbit

biological source

rabbit

biological source

rabbit

isotype

IgG1

isotype

-

isotype

-

isotype

-

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General description

CREB is a beta ZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth and neuronal differentiation in certain neuronal populations. CREB promotes outgrowth and differentiation as a mediator of Neurotrophin pathways. CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+ and stress signaling.

Specificity

Reacts with CREB.

Immunogen

Recombinant CREB-A protein.

Application

Anti-CREB Antibody is a Mouse Monoclonal Antibody for detection of CREB also known as cAMP-response Element Binding Protein & has been validated in ELISA & WB.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Western blot: 1-5 μg/mL. Recognizes the ~43kDa protein.

ELISA: 0.1-1.0 μg/mL

Optimal working dilutions must be determined by end user.

Linkage

Replaces: 04-218

Physical form

Format: Purified
Purified immunoglobulin. Liquid in PBS containing 0.1% sodium azide.

Storage and Stability

Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.

Analysis Note

Control
Jurkat nuclear extract, A-431 whole cell lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Yan-Yan Sun et al.
Scientific reports, 6, 30743-30743 (2016-08-05)
The number and subtype composition of N-methyl-d-aspartate receptor (NMDAR) at synapses determines their functional properties and role in learning and memory. Genetically increased or decreased amount of GluN2B affects hippocampus-dependent memory in the adult brain. But in some experimental conditions
Hong Cao et al.
Neuroscience bulletin, 28(1), 77-87 (2012-01-12)
The rostral anterior cingulate cortex (rACC) is implicated in processing the emotional component of pain. N-methyl-D-aspartate receptors (NMDARs) are highly expressed in the rACC and mediate pain-related affect by activating a signaling pathway that involves cyclic adenosine monophosphate (cAMP)/protein kinase
C E M Fernandes et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 52(5), e8334-e8334 (2019-05-01)
Studies have shown that an injection with the histamine H4 receptor agonist VUF-8430 modulates emotional memory processes. In the present study, the aim was to verify if intraperitoneal (ip) injection of VUF-8430 (500 ng/kg) in mice affects the synthesis of
Wakako Kawarazaki et al.
Journal of the American Society of Nephrology : JASN, 23(6), 997-1007 (2012-03-24)
Experiments with hyperaldosteronemic animals suggest that, despite lowering plasma aldosterone, salt worsens renal injury by paradoxical activation of the mineralocorticoid receptor (MR). Salt and aldosterone synergistically contribute to renal impairment through Rac1-mediated activation of the MR, but whether angiotensin II
Andrew M Chiu et al.
Cell reports, 28(2), 332-341 (2019-07-11)
In mature neurons, postsynaptic N-methyl-D-aspartate receptors (NMDARs) are segregated into two populations, synaptic and extrasynaptic, which differ in localization, function, and associated intracellular cascades. These two pools are connected via lateral diffusion, and receptor exchange between them modulates synaptic NMDAR

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