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MAB5540

Sigma-Aldrich

Anti-Olig1 Antibody

ascites fluid, Chemicon®

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Synonym(s):
Oligo1, Oligodendrocyte transcription factor 1
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

ascites fluid

antibody product type

primary antibodies

clone

monoclonal

species reactivity

human, mouse, rat

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

isotype

IgG2b

NCBI accession no.

NM_138983.1

UniProt accession no.

Q8TAK6

shipped in

dry ice

Gene Information

human ... OLIG1(116448)
rat ... Olig1(60394)

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MAB5540

Anti-Olig1 Antibody

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Anti-Olig-2 Antibody Chemicon®, from rabbit

Sigma-Aldrich

AB9610

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antibody form

ascites fluid

antibody form

purified antibody

antibody form

ascites fluid

antibody form

purified antibody

clone

monoclonal

clone

polyclonal

clone

monoclonal

clone

polyclonal

species reactivity

human, mouse, rat

species reactivity

rat, mouse

species reactivity

ferret, rat, mouse

species reactivity

mouse, human, rat

manufacturer/tradename

Chemicon®

manufacturer/tradename

Chemicon®

manufacturer/tradename

Chemicon®

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable, immunohistochemistry: suitable, western blot: suitable

technique(s)

immunocytochemistry: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable

technique(s)

immunohistochemistry: suitable, western blot: suitable

technique(s)

immunocytochemistry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, immunoprecipitation (IP): suitable, western blot: suitable

General description

Olig-1 is a bHLH transcription factor that is expressed by oligodendrocytes in the brain where it promotes oligodendrocyte formation and maturation. Olig1 cooperates with Olig2 to establish the pMN domain of the embryonic neural tube.

Specificity

Oligodendrocyte marker Olig1. The antibody typically stains cell in either the cytoplasm or nucleus depending on cell type. Staining will be present in the nucleus of remyelinating oligodendrocytes.

Immunogen

Fusion protein from mouse Olig1.

Application

Anti-Olig1 Antibody is an antibody against Olig1 for use in WB, IC, IH.
Research Category
Neuroscience
Research Sub Category
Neuronal & Glial Markers

Physical form

Liquid ascites fluid.

Storage and Stability

Maintain at -20degC in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

Analysis Note

Control
Positive control: Corpus callosium Negative control: skin or non-neural organs

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Mario Marotta et al.
Stem cell research, 22, 33-42 (2017-06-05)
Despite benefits of prenatal in utero repair of myelomeningocele, a severe type of spina bifida aperta, many of these patients will still suffer mild to severe impairment. One potential source of stem cells for new regenerative medicine-based therapeutic approaches for
Elena K Fetisova et al.
Oxidative medicine and cellular longevity, 2019, 2082561-2082561 (2019-07-30)
Multiple sclerosis (MS) is a heterogeneous autoimmune disease of unknown etiology characterized by inflammation, demyelination, and axonal degeneration that affects both the white and gray matter of CNS. Recent large-scale epidemiological and genomic studies identified several genetic and environmental risk
Jenna J Boulanger et al.
Frontiers in neuroscience, 11, 143-143 (2017-04-13)
Key Points Oligodendrocyte precursor cells express doublecortin, a microtubule-associated protein.Oligodendrocyte precursor cells express doublecortin, but at a lower level of expression than in neuronal precursor.Doublecortin is not associated with a potential immature neuronal phenotype in Oligodendrocyte precursor cells. Oligodendrocyte precursor
Hong Zhao et al.
Molecular medicine reports, 20(5), 4603-4611 (2019-11-09)
The differentiation and maturation of oligodendrocyte precursor cells (OPCs) is important for remyelination in the central nervous system. Nevertheless, this process is often limited and incomplete in ischemic injury. Oligodendrocyte transcription factor 1 (Olig1) is important for the maturation of OPCs and
Cui Li et al.
Cell discovery, 4, 43-43 (2018-08-08)
The causal link between Zika virus (ZIKV) infection and microcephaly has raised alarm worldwide. Microglial hyperplasia, reactive gliosis, and myelination delay have been reported in ZIKV-infected microcephalic fetuses. However, whether and how ZIKV infection affects glial cell development remain unclear.
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