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MAB8703

Sigma-Aldrich

Anti-Dengue Virus Type III Antibody, clone 5D4-11

clone 5D4-11, Chemicon®, from mouse

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eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

purified antibody

clone

5D4-11, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

immunofluorescence: suitable

isotype

IgG1

shipped in

wet ice

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antibody form

purified antibody

antibody form

purified antibody

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purified immunoglobulin

antibody form

ascites fluid

clone

5D4-11, monoclonal

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15F3-1, monoclonal

clone

3H5-1, monoclonal

clone

monoclonal

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

manufacturer/tradename

Chemicon®

manufacturer/tradename

Chemicon®

manufacturer/tradename

Chemicon®

manufacturer/tradename

Chemicon®

technique(s)

immunofluorescence: suitable

technique(s)

immunofluorescence: suitable

technique(s)

immunofluorescence: suitable, inhibition assay: suitable (hemagglutination)

technique(s)

immunofluorescence: suitable

General description

Dengue fever is an acute, mosquito-transmitted viral disease characterized by fever, headache, arthralgia (severe retro-orbital pain), myalgia, rash, nausea, and vomiting. Infections are caused by any of the four closely related, but antigenically distinct virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4). Infection with one of these serotypes does not provide cross-protective immunity, so persons living in a dengue-endemic area can have four dengue infections during their lifetimes. Dengue is primarily an urban disease of the tropics, and the viruses that cause it are maintained in a cycle that involves humans and Aedes aegypti, a domestic, day-biting mosquito that prefers to feed on humans. Although most dengue infections result in relatively mild illness, some can produce Dengue Hemorrhagic Fever (DHF) or dengue shock syndrome, with children being particularly at risk. Although epidemic outbreaks have been reported since 1779, the incidence has been increasing, with global, multiple serotype pandemics intensifying within the last 15 years. There is no specific antiviral therapy for dengue, but for both classical dengue and dengue hemorrhagic fever, symptomatic and supportive measures are effective. Important risk factors for DHF include the strain and serotype of the virus involved, as well as the age, immune status, and genetic predisposition of the patient.

Specificity

Reacts with the Dengue type 3 virus.

Immunogen

Dengue virus antigens (H87).

Application

Anti-Dengue Virus Type III Antibody, clone 5D4-11 is an antibody against Dengue Virus Type III for use in IF.
Immunofluorescent assay.

Final working dilutions must be determined by end user.
Research Category
Infectious Diseases
Research Sub Category
Infectious Diseases - Viral

Physical form

Format: Purified
Purified. 0.02M Phosphate Buffer, pH 7.6, 0.25M NaCl and 0.1% sodium azide.

Storage and Stability

Maintain at 2-8°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Zhao Xuan Low et al.
Scientific reports, 11(1), 21221-21221 (2021-10-29)
Dengue is an arthropod-borne viral disease that has become endemic and a global threat in many countries with no effective antiviral drug available currently. This study showed that flavonoids: silymarin and baicalein could inhibit the dengue virus in vitro and
Evaluation by flow cytometry of antibody-dependent enhancement (ADE) of dengue infection by sera from Thai children immunized with a live-attenuated tetravalent dengue vaccine.
Bruno Guy, Pornthep Chanthavanich, Sophie Gimenez, Chukiat Sirivichayakul et al.
Vaccine null
Identification of distinct antigenic determinants on dengue-2 virus using monoclonal antibodies.
Gentry, M K, et al.
The American Journal of Tropical Medicine and Hygiene, 31, 548-555 (1982)
Dengue virus-specific and flavivirus group determinants identified with monoclonal antibodies by indirect immunofluorescence
Henchal, E A, et al
The American Journal of Tropical Medicine and Hygiene, 31, 830-836 (1982)

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