This product is presented in 0.02M phosphate buffer, pH 7.6, 0.25M NaCl, and 0.1% sodium azide. Dilution is suitable in a buffer similar to the storage buffer.
MAB8703
Anti-Dengue Virus Type III Antibody, clone 5D4-11
clone 5D4-11, Chemicon®, from mouse
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
5D4-11, monoclonal
Species reactivity:
human
Application:
IF
Citations:
7
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biological source
mouse
antibody form
purified antibody
clone
5D4-11, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
immunofluorescence: suitable
isotype
IgG1
shipped in
wet ice
Quality Level
1 of 4
This Item | |||
|---|---|---|---|
| antibody form purified antibody | antibody form purified immunoglobulin | antibody form purified immunoglobulin | antibody form ascites fluid |
| biological source mouse | biological source mouse | biological source mouse | biological source mouse |
| clone 5D4-11, monoclonal | clone 3H5-1, monoclonal | clone D3-2H2-9-21, monoclonal | clone monoclonal |
| species reactivity human | species reactivity human | species reactivity human | species reactivity human |
| shipped in wet ice | shipped in wet ice | shipped in wet ice | shipped in wet ice |
| technique(s) immunofluorescence: suitable | technique(s) immunofluorescence: suitable, inhibition assay: suitable (hemagglutination) | technique(s) immunocytochemistry: suitable, immunofluorescence: suitable | technique(s) immunofluorescence: suitable |
General description
Dengue fever is an acute, mosquito-transmitted viral disease characterized by fever, headache, arthralgia (severe retro-orbital pain), myalgia, rash, nausea, and vomiting. Infections are caused by any of the four closely related, but antigenically distinct virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4). Infection with one of these serotypes does not provide cross-protective immunity, so persons living in a dengue-endemic area can have four dengue infections during their lifetimes. Dengue is primarily an urban disease of the tropics, and the viruses that cause it are maintained in a cycle that involves humans and Aedes aegypti, a domestic, day-biting mosquito that prefers to feed on humans. Although most dengue infections result in relatively mild illness, some can produce Dengue Hemorrhagic Fever (DHF) or dengue shock syndrome, with children being particularly at risk. Although epidemic outbreaks have been reported since 1779, the incidence has been increasing, with global, multiple serotype pandemics intensifying within the last 15 years. There is no specific antiviral therapy for dengue, but for both classical dengue and dengue hemorrhagic fever, symptomatic and supportive measures are effective. Important risk factors for DHF include the strain and serotype of the virus involved, as well as the age, immune status, and genetic predisposition of the patient.
Immunogen
Dengue virus antigens (H87).
Application
Anti-Dengue Virus Type III Antibody, clone 5D4-11 is an antibody against Dengue Virus Type III for use in IF.
Immunofluorescent assay.
Final working dilutions must be determined by end user.
Final working dilutions must be determined by end user.
Research Category
Infectious Diseases
Infectious Diseases
Research Sub Category
Infectious Diseases - Viral
Infectious Diseases - Viral
Biochem/physiol Actions
Reacts with the Dengue type 3 virus.
Physical form
Format: Purified
Purified. 0.02M Phosphate Buffer, pH 7.6, 0.25M NaCl and 0.1% sodium azide.
Preparation Note
Maintain at 2-8°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Storage Class
12 - Non Combustible Liquids
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Evaluation by flow cytometry of antibody-dependent enhancement (ADE) of dengue infection by sera from Thai children immunized with a live-attenuated tetravalent dengue vaccine.
Bruno Guy, Pornthep Chanthavanich, Sophie Gimenez, Chukiat Sirivichayakul et al.
Vaccine null
Zhao Xuan Low et al.
Scientific reports, 11(1), 21221-21221 (2021-10-29)
Dengue is an arthropod-borne viral disease that has become endemic and a global threat in many countries with no effective antiviral drug available currently. This study showed that flavonoids: silymarin and baicalein could inhibit the dengue virus in vitro and
Identification of distinct antigenic determinants on dengue-2 virus using monoclonal antibodies.
Gentry, M K, et al.
The American Journal of Tropical Medicine and Hygiene, 31, 548-555 (1982)
Dengue virus-specific and flavivirus group determinants identified with monoclonal antibodies by indirect immunofluorescence
Henchal, E A, et al
The American Journal of Tropical Medicine and Hygiene, 31, 830-836 (1982)
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Hello, We need to dilute this antibody and we don't have the information in which type of liquid the dilution is suitable, can you inform me? Item MAB8703 Batch 3022929
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