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MABMAG-83K

MILLIPLEX® Mouse Amyloid Beta Panel

Configurable Mouse Amyloid Beta 2-Plex Panel

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.47
eCl@ss:
32161000
To order a Milliplex® kit, please search for your analyte of interest.


Product Name

MILLIPLEX® Mouse Amyloid Beta Panel,

Quality Level

description

Configurable Mouse Amyloid Beta 2-Plex Panel

species reactivity

mouse

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

technique(s)

multiplexing: suitable

input

cerebrospinal fluid (CSF)
cell culture supernatant(s)
plasma
serum

assay range

accuracy: 80%
(Spike recovery for Aβ1-40), sensitivity: 3.6 pg/mL
(A?1-40; MinDC+2SD), sensitivity: 4.8 pg/mL
(A?1-42; MinDC+2SD), standard curve range: 3-2500 pg/mL
(Aβ1-40), standard curve range: 7-5000 pg/mL
(Aβ1-42), inter-assay cv: <10%
intra-assay cv: <5%

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

General description

Amyloid Beta 1-40 (Aβ40) and Amyloid Beta 1-42 (Aβ42) are critical biomarkers for Alzheimer′s disease (AD) and other neurodegenerative disorders marked by cognitive decline. Aβ42 is especially relevant as it forms neurotoxic aggregates that disrupt neuronal function, with reduced levels in cerebrospinal fluid (CSF) linked to disease progression. Mouse models of AD are essential for studying these biomarkers, as they provide insights into disease mechanisms and potential therapeutic targets, enhancing our understanding of AD pathology and potential intervention strategies.

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 2 analytes in mouse serum, plasma, cerebrospinal fluid (CSF),and cell culture supernatants.

Analytes included: Amyloid beta 1-40 (Aβ40), Amyloid beta 1-42 (Aβ42).

Note: RANTES cannot be plexed with other cytokines in this panel due to a required 1:100 dilution of plasma/serum samples. This premixed panel comes with a RANTES bead, so please plan your samples accordingly.

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Features and Benefits

  • Unlock Multiplex Power: Experience the efficiency of simultaneous quantification of Aβ40 and Aβ42, allowing you to streamline your research and maximize productivity in neurodegnerative disease studies.
  • Quality You Can Trust: Each kit is rigorously tested, guaranteeing consistent performance and reliability across different lots, so you can focus on your research without worry.
  • Designed for Real-World Samples: Our optimized serum matrix mimics the native environment of analytes, ensuring that your results are as close to real-world conditions as possible.
  • Convenience in Every Box: Say goodbye to the hassle of assembling reagents! Our all-in-one box format provides everything you need for your assays, making your workflow smoother and more efficient.
  • Empower Your Research: Leverage the insights from a precise and accurate assay to advance your understanding of Alzheimer′s disease and other ameyloidopathies.

Legal Information

Luminex is a registered trademark of Luminex Corporation
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

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This Item
MAP2MAG-76KMADKMAG-71KRKTX1MAG-37K
species reactivity

mouse

species reactivity

mouse

species reactivity

mouse

species reactivity

rat

manufacturer/tradename

Milliplex®

manufacturer/tradename

Milliplex®

manufacturer/tradename

Milliplex®

manufacturer/tradename

Milliplex®

assay range

accuracy: 80%
(Spike recovery for Aβ1-40), sensitivity: 4.8 pg/mL
(A?1-42; MinDC+2SD), standard curve range: 7-5000 pg/mL
(Aβ1-42), inter-assay cv: <10%
intra-assay cv: <5%, sensitivity: 3.6 pg/mL
(A?1-40; MinDC+2SD), standard curve range: 3-2500 pg/mL
(Aβ1-40)

assay range

accuracy: 99.2-128.2%, sensitivity: 0.001-7.495 ng/mL, standard curve range: 0.001-0.5 ng/mL
(AGP), standard curve range: 0.005-4.0 ng/mL
(Adipsin), standard curve range: 0.014-10 ng/mL
(CRP), standard curve range: 0.549-400 ng/mL
(Haptoglobin), standard curve range: 13.717-10,000 ng/mL
(SAP), standard curve range: 6.858-5000 ng/mL
(A2M), inter-assay cv: <15%
intra-assay cv: <10%

assay range

accuracy: 77-92%, standard curve range: 12.2-50,000 pg/mL

assay range

accuracy: 70-123%, standard curve range: 0.03-20 ng/mL
(IP-10, KIM-1, OPN), standard curve range: 0.03-20 ng/mL
(VEGF), standard curve range: 0.27-200 ng/mL
(TIMP-1), standard curve range: 2.06-1500 ng/mL
(Clusterin), standard curve range: 4.12-3000 ng/mL
(GSTα), inter-assay cv: <10%
intra-assay cv: <15%
(All other analytes), inter-assay cv: <20%
intra-assay cv: <30%
(GSTα)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

detection method

fluorometric (Luminex® xMAP® technology)

detection method

fluorometric (Luminex® xMAP® technology)

detection method

fluorometric (Luminex® xMAP® technology)

detection method

fluorometric (Luminex® xMAP® technology)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C


signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

Storage Class

10 - Combustible liquids

wgk

WGK 3



Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Gayane Hrachia Buniatian et al.
Cells, 9(2) (2020-02-25)
The function and regulation of amyloid-beta (Aβ) in healthy and diseased liver remains unexplored. Because Aβ reduces the integrity of the blood-brain barrier we have examined its potential role in regulating the sinusoidal permeability of normal and cirrhotic liver. Aβ



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