MilliporeSigma
All Photos(2)

MABN350

Sigma-Aldrich

Anti-NTR1 Antibody, clone 8F11.1

clone 8F11.1, from mouse

Synonym(s):
Neurotensin receptor type 1, NT-R-1, NTR1, High-affinity levocabastine-insensitive neurotensin receptor, NTRH
eCl@ss:
32160702

biological source

mouse

Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

8F11.1, monoclonal

species reactivity

human, mouse

technique(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

isotype

IgG1κ

NCBI accession no.

UniProt accession no.

shipped in

dry ice

Gene Information

human ... TFIP11(24144)

Compare Similar Items

View Full Comparison

1 of 4

This Item
MABS1152MABC182MABS1688
biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

clone

8F11.1, monoclonal

clone

Nt2535-2835, monoclonal

clone

10B11.1, monoclonal

clone

1C6.3, monoclonal

species reactivity

human, mouse

species reactivity

mouse, human

species reactivity

mouse

species reactivity

human

technique(s)

immunohistochemistry: suitable (paraffin), western blot: suitable

technique(s)

ELISA: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, western blot: suitable

technique(s)

western blot: suitable

technique(s)

immunohistochemistry: suitable (paraffin), western blot: suitable

isotype

IgG1κ

isotype

IgG1κ

isotype

IgG2bκ

isotype

IgG2aκ

General description

Neurotensin receptor type 1 (UniProt P30989; also known as High-affinity levocabastine-insensitive neurotensin receptor, NT-R-1, NTR1, NTRH) is encoded by the NTSR1 (also known as NTRR) gene (Gene ID 4923) in human. Neurotensin (NT) is a tridecapeptide that acts as a neuromodulator in the CNS. It also behaves as a hormone in the gastrointestinal tract. Four different NTSRs have been reported. NTSR1 and NTSR2 are seven-transmembrane G-protein-coupled receptors (GPCRs), while NTSR3 and NTSR4 are members of the sortilin protein family with a single-transmembrane spanning domain. NTSR1 is a high affinity NT receptor and plays an important role in cancer cell proliferation, survival, mobility, and invasion. NT has also been implicated in the pathophysiology of several CNS disorders, such as schizophrenia, drug abuse, eating disorders, and Parkinson’s disease.

Immunogen

Epitope: Near C-terminus
KLH-conjugated linear peptide corresponding to human NTR1 near the C-terminus.

Application

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected NTR1 in human thalamus and human frontal cortex tissue.
Research Category
Neuroscience
Research Sub Category
Developmental Signaling
This Anti-NTR1 Antibody, clone 8F11.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of NTR1 .

Quality

Evaluated by Western Blotting in mouse hypothalamus tissue lysate.

Western Blotting Analysis: 2.5 µg/mL of this antibody detected NTR1 in 10 µg of mouse hypothalamus tissue lysate.

Target description

~49 kDa observed. Uncharacterized band(s) may appear in some lysates.

Physical form

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (Example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service