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MABN497

Sigma-Aldrich

Anti-PSD93 Antibody, clone N18/30

clone N18/30, from mouse

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Synonym(s):
Disks large homolog 2, Channel-associated protein of synapse-110, Chapsyn-110, Postsynaptic density protein PSD-93
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

N18/30, monoclonal

species reactivity

human, rat, mouse

technique(s)

immunohistochemistry: suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

rat ... Dlg2(64053)

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Anti-PSD93 Antibody, clone N18/30 clone N18/30, from mouse

MABN497

Anti-PSD93 Antibody, clone N18/30

Anti-PSD95 Antibody, clone K28/43 clone K28/43, from mouse

MABN68

Anti-PSD95 Antibody, clone K28/43

Anti-PSD95 Antibody, clone 3H4.3 clone 3H4.3, from mouse

MABN1194

Anti-PSD95 Antibody, clone 3H4.3

species reactivity

human, rat, mouse

species reactivity

rat

species reactivity

human

species reactivity

mouse, rat, human

clone

N18/30, monoclonal

clone

K28/43, monoclonal

clone

polyclonal

clone

3H4.3, monoclonal

Gene Information

rat ... Dlg2(64053)

Gene Information

human ... DLG4(1742)

Gene Information

human ... DLG4(1742)

Gene Information

human ... DLG4(1742)
rat ... Dlg4(29495)

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

isotype

IgG1κ

isotype

IgG2aκ

isotype

-

isotype

IgG1κ

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General description

As a member of the membrane-associated guanylate kinase (MAGUK) family, PSD93 (also known as Chapsyn-110) binds directly to the N-methyl-D-aspartate (NMDA) receptor and the Shaker K+ channel subunits. It shares 70-80% homology with PSD-95 (SAP90), and SAP97. Like PSD-95, PSD93 plays a key role in postsynaptic targeting. Aside from binding to glutamate receptors, the MAGUK family of proteins also interacts with cell surface structures, like cell adhesion molecules, ion channels, cytoskeletal elements, and signal transduction molecules. Improper PSD93 signaling has been implicated in certain disease states, such as schizophrenia.

Specificity

This antibody does not demonstrate cross reactivity with other MAGUK family members, such as PSD-95, SAP97, and SAP102 expressed in transfected cells.

Immunogen

Recombinant protein corresponding to rat PSD93.

Application

Detect PSD93 using this Anti-PSD93 Antibody, clone N18/30 validated for use in Western Blotting & IHC.
Research Category
Neuroscience
Research Sub Category
Developmental Signaling
Western Blot Analysis: 1 µg/mL from a representative lot detected PSD93 in 10 µg of human brain tissue lysate.

Immunohistochemistry Analysis: A representative lot detected PSD93 in rat brain tissue (Prof. J. Trimmer, University of California, Davis).

Western Blot Analyis: A representative lot detected PSD93 in WT, but not in PSD93 knockout mice.

Western Blot Analysis: A representative lot detected PSD93 in CA1 tissue lysates from C57BL/6 mice (Jeffrey, R. A., et al. (2009). J Neurosci. 29(50):15613-15620.).

Quality

Evaluated by Western Blot in mouse brain tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected PSD93 in 10 µg of mouse brain tissue lysate.

Target description

~110 kDa observed. The calculated molecular weight of PSD93 is 95 kDa; however, this protein is highly phosphorylated and is observed at ~110 kDa Multiple isoforms between 68-98 kDa are known to exist.

Physical form

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Mouse brain tissue lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Christopher J Alexander et al.
Cerebellum (London, England), 18(3), 406-421 (2019-02-08)
While mixed primary cerebellar cultures prepared from embryonic tissue have proven valuable for dissecting structure-function relationships in cerebellar Purkinje neurons (PNs), this technique is technically challenging and often yields few cells. Recently, mouse embryonic stem cells (mESCs) have been successfully
Austin A Coley et al.
Scientific reports, 9(1), 9486-9486 (2019-07-03)
Postsynaptic density protein-95 (PSD-95) is a major regulator in the maturation of excitatory synapses by interacting and trafficking N-methyl-D-aspartic acid receptors (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isox-azoleproprionic acid receptors (AMPAR) to the postsynaptic membrane. PSD-95 disruption has recently been associated with neuropsychiatric disorders

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