MABN503

Anti-WAVE-1 Antibody, clone K91/36

clone K91/36, from mouse

• Synonym(s): Wiskott-Aldrich syndrome protein family member 1, WASP family protein member 1, Protein WAVE-1, Verprolin homology domain-containing protein 1
• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702
• Conjugate: unconjugated
• Clone: K91/36, monoclonal
• Application: IHC, WB
• Citations: 4

Properties

• biological source: mouse
• Quality Level: 100
• conjugate: unconjugated
• antibody form: purified antibody
• antibody product type: primary antibodies
• clone: K91/36, monoclonal
• species reactivity: human, mouse, rat
• technique(s): immunohistochemistry: suitable, western blot: suitable
• isotype: IgG1κ
• NCBI accession no.: NP_001020105
• UniProt accession no.: Q92558
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... WASF1(8936)

Description

General description

Protein WAVE-1 (WAVE1) is also known as Wiskott-Aldrich syndrome protein (WASP) family member 1 (WASF1), verprolin homology domain-containing protein 1, or SCAR1. WAVE1 is a downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. WAVE1 binds actin and ARP2/3 complex. It binds the ARP2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain. WAVE1 is highly expressed in brain, with low expression in several other tissue.

~ 70 kDa observed

Immunogen

Linear peptide corresponding to human WAVE-1.

Application

Detect WAVE1 using this mouse monoclonal antibody, Anti-WAVE-1 Antibody, clone K91/36 validated for use in western blotting & IHC.

Immunohistochemistry Analysis: A representative lot detected WAVE-1 in adult rat hippocampal CA1 tissue (Prof. J. Trimmer, University of California, Davis).

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

Physical form

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Rat brain tissue lysate

Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected WAVE-1 in 10 µg of rat brain tissue lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable