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MABS1284-B

Sigma-Aldrich

Anti-Apolipoprotein(a) Antibody, clone LPA4 Antibody, Biotin Conjugate

clone LPA4, from mouse, biotin conjugate

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Synonym(s):
Apo(a), Lp(a)
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

biotin conjugate

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

LPA4, monoclonal

species reactivity

human, nonhuman primates

technique(s)

ELISA: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1κ

UniProt accession no.

shipped in

ambient

target post-translational modification

unmodified

Gene Information

human ... APOA1(335)

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MABS1310ABS434MABS385
Anti-ApoA4 Antibody from rabbit, purified by affinity chromatography

Sigma-Aldrich

ABS434

Anti-ApoA4 Antibody

conjugate

biotin conjugate

conjugate

-

conjugate

-

conjugate

-

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

ascites fluid

clone

LPA4, monoclonal

clone

Wt20-7, monoclonal

clone

polyclonal

clone

1D4, monoclonal

species reactivity

human, nonhuman primates

species reactivity

human

species reactivity

human

species reactivity

human

technique(s)

ELISA: suitable, immunoprecipitation (IP): suitable, western blot: suitable

technique(s)

ELISA: suitable, dot blot: suitable, immunocytochemistry: suitable, western blot: suitable

technique(s)

immunohistochemistry: suitable, western blot: suitable

technique(s)

western blot: suitable

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General description

Apolipoprotein(a) (UniProt P08519; also known as Apo(a), Lp(a)) is encoded by the LPA gene (Gene ID 4018) in human. Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It is synthesized with a signal peptide (aa 1-19) that is subsequently cleaved off. Lipoprotein (a)/Lp(a) is composed of Apo(a) covalently bound to apolipoprotein B-100/ApoB via a single disulfide bond on kringle (K)IV type 9 (KIV9) to a site near ApoB low density lipoprotein (LDL) receptor-binding site. Structurally, Apo (a) contains ten subtypes of KIV sequences, with the KIV2 subtype present in multiple identical repeats, followed by a KV sequence and an inactive protease domain. Elevated levels of Lp(a) are considered as a risk factor in the development of cardiovascular diseases and peripheral arterial disease. Lp(a) is a preferential lipoprotein carrier of oxidized phospholipids (OxPLs) and circulating levels of oxidized LDL are strongly associated with angiographically documented coronary artery disease. Apo(a) is known to be proteolytically cleaved. Apo(a) fragments accumulate in atherosclerotic lesions, where they may promote thrombogenesis.

Specificity

Clone LPA4 detects Apolipoprotein(a) in human and non-human primates.

Immunogen

Human Lipoprotein a (Lp(a)).

Application

Anti-Apolipoprotein(a), clone LPA4, Biotin Conjugate, Cat. No. MABS1284-B, is a mouse monoclonal antibody that detects Apolipoprotein (a)/Apo(a)/Lp(a) in human and non-human primates and has been tested for use in ELISA, Immunoprecipitation, and Western Blotting.
ELISA Analysis: A representative lot detected Apolipoprotein(a) in ELISA applications (Pedersen, T.X., et. al. (2010). J Lipid Res. 51(10):2967-75; Leibundgut, G., et. al. (2013). J Lipid Res. 54(10):2815-30).

ELISA Analysis: 0.1 µg/mL from a representative lot detected Apolipoprotein(a) in Patient Lp(a) Plasma sample (Courtesy of Dr. Sotirios Tsimikas, M.D., University of California at San Diego, USA).

Immunoprecipitation Analysis: A representative lot detected Apolipoprotein(a) in Immunoprecipitation applications (Tsimikas, S., et. al. (2004). Circulation. 109(25):3164-70).

Western Blotting Analysis: A representative lot detected Apolipoprotein(a) in Western Blotting applications (Leibundgut, G., et. al. (2013). J Lipid Res. 54(10):2815-30).
Research Category
Signaling

Quality

N/A

Target description

501.32 kDa calculated for Apolipoprotein A

Physical form

Protein G purified
Purified mouse monoclonal antibody IgG1 in PBS with 1.5% BSA and 0.1% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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