MABT198

Anti-Connexin-26 Antibody, clone 3B12.1

clone 3B12.1, from mouse

• Synonym(s): Gap junction beta-2 protein, Connexin-26, Cx26
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• biological source: mouse
• Quality Level: 100; 200
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 3B12.1, monoclonal
• species reactivity: rat, human
• technique(s): immunohistochemistry: suitable; western blot: suitable
• isotype: IgG1κ
• NCBI accession no.: NP_003995
• UniProt accession no.: P29033
• shipped in: wet ice
• Gene Information: human ... GJB2(2706)

Description

General description

Connexin-2 is also known as Connexin Gap junction beta-2 protein (GJB2) and Connexin-26 (Cx26). The connexins are transmembrane channels that diffuse low MW materials from one cell to a neighboring cell. Aberrant connexin-2 can cause deafness autosomal recessive type 1A (DFNB1A), deafness autosomal dominant type 3A (DFNA3A), Vohwinkel syndrome (VS), palmoplantar keratoderma with deafness (PPKDFN), keratitis-ichthyosis-deafness syndrome (KID syndrome), Bart-Pumphrey syndrome (BPS), and ichthyosis hystrix-like with deafness syndrome (HID syndrome).

Specificity

Other homologies: Mouse (92% sequence homology).

Immunogen

KLH-conjugated linear peptide corresponding to human Connexin-26.

Application

Anti-Connexin-26 Antibody, clone 3B12.1 is a highly specific mouse monoclonal antibody, that targets CX26 & has been tested in western blotting & IHC.

Immunohistochemistry Analysis: A 1:4,000-8,000 dilution from a representative lot detected Connexin-26 in human colon and human liver tissue.

Research Category
Cell Structure

Research Sub Category
Adhesion (CAMs)

Quality

Evaluated by Western Blotting in rat liver tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Connexin-26 in 10 µg of rat liver tissue lysate.

Target description

~26 kDa observed

Physical form

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Rat liver tissue lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable