MATFLAGELLIN
FLAGELLIN Non-Endotoxin Pyrogen (NEP) Control
for use with PyroMAT® System
Synonym(s):
NEP, NEP Control
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About This Item
UNSPSC Code:
41116130
NACRES:
NA.24
eCl@ss:
32160606
Suitability:
pyrogenic bacteria
Manufacturer/tradename:
PyroMAT®
Application(s):
pharmaceutical
pyrogen testing
pyrogen testing
Storage temp.:
−20°C
Quality Segment
product line
PyroMAT®
feature
Non-endotoxin pyrogen control of flagellin for use in monocyte activation test
manufacturer/tradename
PyroMAT®
application(s)
pharmaceutical
pyrogen testing
compatibility
configured for PyroDetect System, for use with PyroMAT® System
shipped in
cooler
storage temp.
−20°C
suitability
pyrogenic bacteria
General description
The PyroMAT® System uses cryopreserved Mono-Mac-6 (MM6) human monocytic cells as a source of monocytes. The response to a full range of pyrogens, including endotoxins and non-endotoxin pyrogens (NEPs)is determined by the measurement of interleukin-6 (IL-6) produced by the Mono-Mac-6 cells using ELISA.
NEP control flagellin is a preparation of flagellin from Salmonella typhimurium and supplied in a lyophilized form. Flagellin is a non-endotoxin pyrogen (NEP) that activates the TLR5 receptor of monocytes and can be used as a positive control with the PyroMAT® System (Monocyte Activation Test for pyrogen detection).
NEP control flagellin is a preparation of flagellin from Salmonella typhimurium and supplied in a lyophilized form. Flagellin is a non-endotoxin pyrogen (NEP) that activates the TLR5 receptor of monocytes and can be used as a positive control with the PyroMAT® System (Monocyte Activation Test for pyrogen detection).
Application
NEP control of flagellin can be used as a positive control with the PyroMAT® System. It is to be used for Product Specific Validation (PSV) and routine testing to show that the system can detect non-endotoxin pyrogen contaminants in pharmaceutical products.
Biochem/physiol Actions
TLR-5 agonist
Features and Benefits
Endotoxin-free product at concentration of use in MAT
Preparation Note
Store unopened vials at -20°C
Do not use unopened vials after expiration date
Store resuspended aliquots at -20°C
Do not use unopened vials after expiration date
Store resuspended aliquots at -20°C
Legal Information
PYROMAT is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
13 - Non Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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