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MKI1MAG-94K

Millipore

MILLIPLEX® Mouse Kidney Injury Magnetic Bead Panel 1 - Toxicity Multiplex Assay

The analytes available for this multiplex kit are: β-2-Microglobulin, IP-10, KIM-1, Renin, TIMP-1, VEGF (for urine samples) or IP-10, KIM-1, Renin, and TIMP-1 (for serum/plasma samples).

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eCl@ss:
32161000

Quality Level

200

species reactivity

mouse

manufacturer/tradename

Milliplex®

assay range

accuracy: 73-98%
sensitivity: 0.001-0.041 ng/mL
(MinDC+2SD)
standard curve range: 0.001-1 ng/mL
(VEGF)
standard curve range: 0.005-5 ng/mL
(IP-10)
standard curve range: 0.01-15 ng/mL
(KIM-1)
standard curve range: 0.02-25 ng/mL
(TIMP-1)
standard curve range: 0.05-50 ng/mL
(β-2-Microglobulin)
standard curve range: 0.05-50 ng/mL
(Renin)

technique(s)

multiplexing: suitable

detection method

fluorometric (Luminex xMAP)

shipped in

wet ice

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MILLIPLEX® Mouse Kidney Injury Magnetic Bead Panel 1 - Toxicity Multiplex Assay The analytes available for this multiplex kit are: β-2-Microglobulin, IP-10, KIM-1, Renin, TIMP-1, VEGF (for urine samples) or IP-10, KIM-1, Renin, and TIMP-1 (for serum/plasma samples).

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MILLIPLEX® Mouse Kidney Injury Magnetic Bead Panel 2 - Toxicity Multiplex Assay The analytes available for this multiplex kit are: Clusterin, Cystatin C, EGF, Lipocalin-2/NGAL, Osteopontin (OPN) (for urine samples) or Clusterin, Cystatin C, Lipocalin-2/NGAL, Osteopontin (OPN) (for serum/plasma samples).

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MILLIPLEX® Mouse Kidney Injury Magnetic Bead Panel 2 - Toxicity Multiplex Assay

MILLIPLEX® Human Kidney Injury Magnetic Bead Panel 2 - Toxicity Multiplex Assay The analytes available for this multiplex kit are: α-1-Microglobulin, Albumin, Clusterin, Cystatin C, EGF, Lipocalin-2/NGAL, and Osteopontin (OPN).

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HKI2MAG-99K

MILLIPLEX® Human Kidney Injury Magnetic Bead Panel 2 - Toxicity Multiplex Assay

MILLIPLEX® Human Kidney Injury Magnetic Bead Panel 6 - Toxicity Multiplex Assay The analytes available for this multiplex kit are: β-2-Microglobulin (β2M), Clusterin, Cystatin C, RBP4.

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HKI6MAG-99K

MILLIPLEX® Human Kidney Injury Magnetic Bead Panel 6 - Toxicity Multiplex Assay

manufacturer/tradename

Milliplex®

manufacturer/tradename

Milliplex®

manufacturer/tradename

Milliplex®

manufacturer/tradename

Milliplex®

assay range

accuracy: 73-98%, sensitivity: 0.001-0.041 ng/mL
(MinDC+2SD), standard curve range: 0.001-1 ng/mL
(VEGF), standard curve range: 0.005-5 ng/mL
(IP-10), standard curve range: 0.01-15 ng/mL
(KIM-1), standard curve range: 0.02-25 ng/mL
(TIMP-1), standard curve range: 0.05-50 ng/mL
(β-2-Microglobulin), standard curve range: 0.05-50 ng/mL
(Renin)

assay range

accuracy: 90-99%, sensitivity: 0.005-0.190 ng/mL
(MinDC+2SD), standard curve range: 0.005-5 ng/mL
(Lipocalin-2/NGAL), standard curve range: 0.01-10 ng/mL
(Osteopontin (OPN)), standard curve range: 0.04-40 ng/mL
(EGF), standard curve range: 0.05-50 ng/mL
(Cystatin C), standard curve range: 0.2-250 ng/mL
(Clusterin)

assay range

accuracy: 95-109%, sensitivity: 0.015-5.359 ng/mL
(MinDC = 2SD), standard curve range: 0.01-10 ng/mL
(EGF), standard curve range: 0.02-20 ng/mL
(Lipocalin-2/ NGAL), standard curve range: 0.20-200 ng/mL
(Cystatin C), standard curve range: 0.59-600 ng/mL
(Osteopontin (OPN)), standard curve range: 0.98-1,000 ng/mL
(α-1-Microglobulin), standard curve range: 3.91-4,000 ng/mL
(Albumin), standard curve range: 4.88-5,000 ng/mL
(Clusterin), inter-assay cv: <20%
intra-assay cv: <10%

assay range

accuracy: 103-133%, intra-assay cv: <10, sensitivity: 0.10-3.42 ng/mL
(MinDC+2SD), standard curve range: 0.05-50 ng/mL
(β-2-Microglobulin (β2M)), standard curve range: 0.10-100 ng/mL
(RBP4), standard curve range: 0.59-600 ng/mL
(Cystatin C), standard curve range: 2.93-3,000 ng/mL
(Clusterin)

technique(s)

multiplexing: suitable

technique(s)

multiplexing: suitable

technique(s)

multiplexing: suitable

technique(s)

multiplexing: suitable

detection method

fluorometric (Luminex xMAP)

detection method

fluorometric (Luminex xMAP)

detection method

fluorometric (Luminex xMAP)

detection method

fluorometric (Luminex xMAP)

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

General description

The MILLIPLEX® Mouse Kidney Injury Bead Panel 1 contains all the components necessary to measure the following six biomarkers in any combination using Luminex® xMAP® technology: β-2-Microglobulin, IP-10, KIM-1, Renin, TIMP-1, VEGF. The kit uses a 96-well format, contains a lyophilized standard cocktail, two quality controls and can measure up to 38 urine samples in duplicate.

Application

  • Analytes: β-2-Microglobulin, IP-10, KIM-1, Renin TIMP-1, VEGF
  • Recommended Sample type: urine
  • Recommended Sample dilution: 1:25
  • Assay Run Time: overnight
  • Research Category: Toxicity

Features and Benefits

Design your multiplex kit by choosing available analytes within this panel.

Other Notes

Please contact Technical Service for linearity of dilution.
Sensitivity: Please see kit protocol for individual assay sensitivities.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

Target Organs

Respiratory Tract

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

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Karima Relizani et al.
Molecular therapy. Nucleic acids, 8, 144-157 (2017-09-18)
Antisense oligonucleotides (AONs) hold promise for therapeutic splice-switching correction in many genetic diseases. However, despite advances in AON chemistry and design, systemic use of AONs is limited due to poor tissue uptake and sufficient therapeutic efficacy is still difficult to
Lucía Echevarría et al.
Methods in molecular biology (Clifton, N.J.), 2434, 371-384 (2022-02-26)
Antisense oligonucleotides (ASO) therapeutics hold great promise for the treatment of numerous diseases, and several ASO drugs have now reached market approval, confirming the potential of this approach. However, some candidates have also failed, due to limited biodistribution/uptake and poor
Karima Relizani et al.
Nucleic acids research, 50(1), 17-34 (2021-12-12)
Tricyclo-DNA (tcDNA) is a conformationally constrained oligonucleotide analog that has demonstrated great therapeutic potential as antisense oligonucleotide (ASO) for several diseases. Like most ASOs in clinical development, tcDNA were modified with phosphorothioate (PS) backbone for therapeutic purposes in order to
Gene Ryan Crislip et al.
Biomolecules, 12(2) (2022-02-26)
BMAL1 is a core mammalian circadian clock transcription factor responsible for the regulation of the expression of thousands of genes. Previously, male skeletal-muscle-specific BMAL1-inducible-knockout (iMS-BMAL1 KO) mice have been described as a model that exhibits an aging-like phenotype with an
Monica Javidnia et al.
Journal of Alzheimer's disease : JAD, 60(2), 461-481 (2017-09-05)
Hyperphosphorylation and aggregation of tau protein is a critical factor in many neurodegenerative diseases. These diseases are increasing in prevalence, and there are currently no cures. Previous work from our group and others has shown that tyrosine kinase inhibitors (TKIs)
View All Related Papers

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