MilliporeSigma
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RV2MAG-26K

Millipore

MILLIPLEX® Rat Vascular Injury Magnetic Bead Panel 2 - Toxicity Multiplex Assay

The analytes available for this multiplex kit are: Adiponectin, sE-Selectin, and sICAM-1.

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Synonym(s):
Luminex® Rat Vascualr Injury Panel, Millipore Rat Vascualr Injury Panel, Rat Adiponectin Assay, Rat Vascular Injury Multiplex Assay
eCl@ss:
32161000

Quality Level

species reactivity

rat

manufacturer/tradename

Milliplex®

assay range

accuracy: 67-92%
standard curve range: 0.1-40 ng/mL
(sICAM-1)

standard curve range: 0.1-50 ng/mL
(sE-Selectin)

standard curve range: 0.3-250 ng/mL
(Adiponectin)

standard curve range: 0.7-500 ng/mL
(von Willebrand Factor (vWF))

technique(s)

multiplexing: suitable

detection method

fluorometric (Luminex xMAP)

shipped in

wet ice

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manufacturer/tradename

Milliplex®

manufacturer/tradename

Milliplex®

manufacturer/tradename

Milliplex®

manufacturer/tradename

Milliplex®

assay range

accuracy: 67-92%, standard curve range: 0.1-40 ng/mL
(sICAM-1), standard curve range: 0.1-50 ng/mL
(sE-Selectin), standard curve range: 0.3-250 ng/mL
(Adiponectin), standard curve range: 0.7-500 ng/mL
(von Willebrand Factor (vWF))

assay range

accuracy: 91-102%, standard curve range: 0.1-100 ng/mL
(α-2-Macroglobulin (A2M)), standard curve range: 0.3-200 ng/mL
(Haptoglobin), standard curve range: 0.4-300 ng/mL
(α-1-Acid Glycoprotein (AGP))

assay range

accuracy: 77-92%, sensitivity: 0.021-4.038 ng/mL
(MinDC+2SD), standard curve range: 0.02-15.0 ng/mL
(GSTα), standard curve range: 0.04-30.0 ng/mL
(5′-NT/CD73), standard curve range: 0.08-60.0 ng/mL
(GOT1), standard curve range: 0.10-75.0 ng/mL
(ARG1), standard curve range: 0.62-450.0 ng/mL
(SDH)

assay range

accuracy: 80-131%, standard curve range: 0.2-1,000 pg/mL
(EGF), standard curve range: 12.2-50,000 pg/mL
(GM-CSF, IL-1α, IL-2, IL-12 (p70), IL-18), standard curve range: 14.6-60,000 pg/mL
(Leptin, IFNγ, GRO/KC/CINC-1), standard curve range: 2.4-10,000 pg/mL
(MIP-1α, IL-1β, IP-10, Fractalkine, TNFα), standard curve range: 24.4-100,000 pg/mL
(LIX, MIP-2), standard curve range: 29.3-120,000 pg/mL
(MCP-1), standard curve range: 4.9-20,000 pg/mL
(G-CSF, Eotaxin, IL-4, IL-13, IL-5, VEGF, RANTES), standard curve range: 7.3-30,000 pg/mL
(IL-10, IL-17A), standard curve range: 73.2-300,000 pg/mL
(IL-6)

technique(s)

multiplexing: suitable

technique(s)

multiplexing: suitable

technique(s)

multiplexing: suitable

technique(s)

multiplexing: suitable

detection method

fluorometric (Luminex xMAP)

detection method

fluorometric (Luminex xMAP)

detection method

fluorometric (Luminex xMAP)

detection method

fluorometric (Luminex xMAP)

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

General description

Vascular injury is important to address during the preclinical safety study of drugs. A lack of well-defined mechanisms of drug-induced vascular injury (DIVI) in animals, and the absence of specific, qualified biomarkers have become significant barriers in the development of new therapeutic treatments. In the past, hemodynamics, such as heart rate and mean arterial blood pressure, were used to measure DIVI risks but these only targeted single biomarkers. Today, some of the known vascular injury mechanisms are related to vascular wall shear and/or circumferential “hoop” stress, drug/chemical toxicity, and immunological mediation. With these known biomechanics, primary targets (smooth muscle, endothelial and immune-mediated cells) yield a number of promising candidate biomarkers for DIVI study. We provide valuable research assays to investigate multiple biomarkers of vascular injury in rat serum and plasma samples using the Luminex® xMAP® instrument platform.

The MILLIPLEX® Rat Vascular Injury Bead Panel 2 contains all the components necessary to measure the following four biomarkers in any combination using Luminex® xMAP® technology: Adiponectin, sE-Selectin, sICAM-1, von Willebrand Factor (vWF). The kit uses a 96-well format, contains a lyophilized standard cocktail, two quality controls and can measure up to 38 serum or plasma samples in duplicate.

Panel Type: Toxicity

Specificity

There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes within a panel.

Application

  • Analytes: Adiponectin, sE-Selectin, sICAM-1, von Willebrand Factor (vWF)
  • Recommended Sample type: serum and plasma
  • Recommended Sample dilution: 1:80
  • Assay Run Time: Overnight
  • Research Category: Toxicity

Features and Benefits

Design your multiplex kit by choosing available analytes within this panel.

Packaging

Everything you need in a single kit.

Storage and Stability

Recommended storage for kit components is 2 - 8°C.

Other Notes

Please contact Technical Service for linearity of dilution.
Sensitivity: See kit protocol for individual analytes sensitivities.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pictograms

Skull and crossbonesEnvironment

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3


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Geoffrey P Dobson et al.
Annals of medicine and surgery (2012), 71, 102970-102970 (2021-11-09)
The trauma of surgery is a neglected area of research. Our aim was to examine the differential expression of genes of stress, metabolism and inflammation in the major organs of a rat following a laparotomy. Anaesthetised Sprague-Dawley rats were randomised
Makiko Ohshima et al.
Scientific reports, 6, 39377-39377 (2016-12-21)
Severe intrauterine ischemia is detrimental to the developing brain. The impact of mild intrauterine hypoperfusion on neurological development, however, is still unclear. We induced mild intrauterine hypoperfusion in rats on embryonic day 17 via arterial stenosis with metal microcoils wrapped
Fabrice Antigny et al.
Circulation, 133(14), 1371-1385 (2016-02-26)
Mutations in the KCNK3 gene have been identified in some patients suffering from heritable pulmonary arterial hypertension (PAH). KCNK3 encodes an outward rectifier K(+) channel, and each identified mutation leads to a loss of function. However, the pathophysiological role of

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