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SCT038

Sigma-Aldrich

BioTracker Orange OH and HClO Dye

Live cell imaging probe to detect hydroxy radical (OH) or hypochlorous acid (HClO) in live cells.

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About This Item

UNSPSC Code:
12352207
NACRES:
NA.47

form

lyophilized

application(s)

cell analysis

detection method

fluorometric

General description

Reactive oxygen species (ROS) are important mediators in a variety of biological and pathological events. For example, ROS generated in mitochondria play important roles in the modulation of signal transduction cascades and transcription factors. However, oxidative stress due to excessive generation of ROS is implicated in many human diseases, including acute and chronic inflammatory processes, ischemic stroke, diabetes, sepsis, ischemia-reperfusion injury, atherosclerosis, and neurodegenerative disorders.BioTracker Orange OH and HClO Dye is an orange fluorescent probe to detect hydroxy radical (・OH) or hypochlorous acid (HClO) in live-cell imaging. It can detect -OH and HClO among other reactive oxygen species (O2-, H2O2, NO, ONOO-). Its nearly red fluorescence spectrum allows multicolor imaging with green (ex. GFP, FITC) and blue (ex. Hoechst 33342) fluorophores. Because of its positive charge, OxiORANGE tends to localize within mitochondria. It has high photostability and is suitable for time-lapse imaging of intracellular hROS generation.Spectral Properties:Absorbance (max): 553mEmission (max): 577nmResearch Category:Live Cell Dye

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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