ST1042

Anti-PKD2 Rabbit pAb

Name: Anti-PKD2 Rabbit pAb
Brand: MM

liquid, Calbiochem^®

Synonym(s):

Anti-Protein Kinase D2

Slide 1 of 1

About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Clone:

polyclonal

Species reactivity:

human

Application:

—

Citations:

This product is discontinued. Contact Technical Servicefor assistance.

Key Documents

View All Documentation

biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

liquid

contains

≤0.1% sodium azide as preservative

species reactivity

human

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

dilution

(Immunoblotting (1:500-1:5000)
Immunoprecipitation (1-4 µg/mg lysate))

isotype

IgG

shipped in

wet ice

Quality Level

100

Gene Information

human ... PKD2(5311)

storage temp.

2-8°C

target post-translational modification

unmodified

Related Categories

Primary Antibodies

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item	AP1063	423500	PC548
Sigma-Aldrich ST1042 Anti-PKD2 Rabbit pAb	Sigma-Aldrich AP1063 PhosphoDetect Anti-PDH-E1α (pSer²³²) Rabbit pAb	Sigma-Aldrich 423500 Anti-Klotho Rabbit pAb	Sigma-Aldrich PC548 Anti-Porin (Ab-5) (185-197) Rabbit pAb
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 100
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
species reactivity human	species reactivity mouse, human, rat	species reactivity mouse	species reactivity human, rat
clone polyclonal	clone polyclonal	clone polyclonal	clone polyclonal
storage temp. 2-8°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C

General description

Immunoaffinity purified rabbit polyclonal antibody. Recognizes the ~105 kDa PKD2 protein.

Recognizes the ~105 kDa PKD2 protein in HEK293 cells.

This Anti-PKD2 Rabbit pAb is validated for use in Immunoblotting, Immunoprecipitation for the detection of PKD2.

Immunogen

Human

a synthetic peptide corresponding to amino acids near the C-terminus of human PKD2

Application

Immunoblotting (1:500-1:5000)
Immunoprecipitation (1-4 g/mg lysate)

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

In PBS.

Preparation Note

Following initial use, aliquot and freeze (-20°C) for long-term storage. Avoid freeze/thaw.

Analysis Note

Positive Control
HEK 293 cells

Other Notes

Rey, O., et al. 2003. Biochem. Biophys. Res. Commun.302, 817.
Sturany, S., et al. 2002. J. Biol. Chem.277, 29431.
Sturany, S., et al. 2001. J. Biol. Chem.276, 3310.

This antibody does not cross-react with PKD1 or PKD3. Antibody should be titrated for optimal use in individual systems.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Highly Toxic (H)

Not finding the right product?

Try our Product Selector Tool.

Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Protein kinase D isoforms are activated in an agonist-specific manner in cardiomyocytes.

Jianfen Guo et al.

The Journal of biological chemistry, 286(8), 6500-6509 (2010-12-16)

Protein kinase D (PKD) exists as a family of structurally related enzymes that are activated through similar phosphorylation-dependent mechanisms involving protein kinase C (PKC). While individual PKD isoforms could in theory mediate distinct biological functions, previous studies identify a high

A Novel Conserved Domain Mediates Dimerization of Protein Kinase D (PKD) Isoforms: DIMERIZATION IS ESSENTIAL FOR PKD-DEPENDENT REGULATION OF SECRETION AND INNATE IMMUNITY.

Clara Aicart-Ramos et al.

The Journal of biological chemistry, 291(45), 23516-23531 (2016-09-25)

Protein kinase D (PKD) isoforms are protein kinase C effectors in signaling pathways regulated by diacylglycerol. Important physiological processes (including secretion, immune responses, motility, and transcription) are placed under diacylglycerol control by the distinctive substrate specificity and subcellular distribution of

Protein Kinase D2 Assembles a Multiprotein Complex at the Trans-Golgi Network to Regulate Matrix Metalloproteinase Secretion.

Tim Eiseler et al.

The Journal of biological chemistry, 291(1), 462-477 (2015-10-29)

Vesicle formation and fission are tightly regulated at the trans-Golgi network (TGN) during constitutive secretion. Two major protein families regulate these processes: members of the adenosyl-ribosylation factor family of small G-proteins (ARFs) and the protein kinase D (PKD) family of

Protein Kinase D1, Reduced in Human Pancreatic Tumors, Increases Secretion of Small Extracellular Vesicles From Cancer Cells That Promote Metastasis to Lung in Mice.

Milena Armacki et al.

Gastroenterology, 159(3), 1019-1035 (2020-05-25)

Pancreatic tumor cells release small extracellular vesicles (sEVs, exosomes) that contain lipids and proteins, RNA, and DNA molecules that might promote formation of metastases. It is not clear what cargo these vesicles contain and how they are released. Protein kinase

PKD regulates actin polymerization, neutrophil deformability, and transendothelial migration in response to fMLP and trauma.

Christoph Wille et al.

Journal of leukocyte biology, 104(3), 615-630 (2018-04-16)

Neutrophils are important mediators of the innate immune defense and of the host response to a physical trauma. Because aberrant infiltration of injured sites by neutrophils was shown to cause adverse effects after trauma, we investigated how neutrophil infiltration could

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service