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ST1625

Sigma-Aldrich

Anti-SMAD7 Mouse mAb (4E1)

liquid, clone 4E1, Calbiochem®

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About This Item

UNSPSC Code:
12352203

biological source

mouse

Quality Level

antibody form

purified antibody

antibody product type

primary antibodies

clone

4E1, monoclonal

form

liquid

does not contain

preservative

species reactivity

human

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

isotype

IgG2a

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SMAD7(4092)

General description

Purified mouse monoclonal antibody. Recognizes the ~40-45 kDa SMAD7 protein.
Recognizes the ~40-45 kDa SMAD7 protein in HeLa and U-2 OS cells and human placenta tissue.
This Anti-SMAD7 Mouse mAb (4E1) is validated for use in Immunoblotting for the detection of SMAD7.

Immunogen

A recombinant polypeptide corresponding to amino acids of 160-261 human SMAD7, expressed as a GST fusion protein

Application




Immunoblotting (1-5 g/ml)

Warning

Toxicity: Regulatory Review (Z)

Physical form

In PBS, pH 7.2.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Analysis Note

Positive Control
Human placenta tissue, HeLa cells, U-2 OS cells

Other Notes

Variables associated with assay conditions will dictate the proper working dilution.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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Chih-Hau Chang et al.
International journal of molecular sciences, 18(9) (2017-09-08)
Restoring sufficient vascularity of the ischemia/hypoxia flap is always the critical issue in flap surgeries. In a previous studies microRNA-21 (miR-21) expression was upregulated after rat skin flap surgery. MiR-21 has been reported to be induced by hypoxia and the
Genaro Rodríguez-Uribe et al.
BioMed research international, 2018, 2847873-2847873 (2018-06-12)
This work aimed to determine if cataractous changes associated with EMT occurring in the K14E6 mice lenses are associated with TGF-β and Wnt/β-catenin signaling activation. Cataracts of K14E6 mice were analysed histologically; and components of TGF-β and Wnt/β-catenin signaling were
Chi-Ting Su et al.
Human molecular genetics, 24(14), 4024-4036 (2015-04-18)
Mutations in the gene for the latent transforming growth factor beta binding protein 4 (LTBP4) cause autosomal recessive cutis laxa type 1C. To understand the molecular disease mechanisms of this disease, we investigated the impact of LTBP4 loss on transforming

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