10127647001

Glucose-6-phosphate

mol wt (glucose-6-P: Mr = 260.2, glucose-6-P-Na2: Mr = 304.2), pkg of 5 g

• Synonym(s): D-Glucose 6-phosphate disodium salt hydrate, G-6-P-Na₂, Robison ester
• Empirical Formula (Hill Notation): C₆H₁₁Na₂O₉P · xH₂O
• CAS Number: 3671-99-6
• Molecular Weight: 304.10 (anhydrous basis)
• PubChem Substance ID: 329748950
• UNSPSC Code: 12352302
• Beilstein/REAXYS Number: 5199009
• MDL number: MFCD00150940
• NACRES: NA.54

Properties

• form: solid
• mol wt: (glucose-6-P: Mr = 260.2, glucose-6-P-Na2: Mr = 304.2)
• packaging: pkg of 5 g
• manufacturer/tradename: Roche
• shipped in: ambient
• SMILES string: O.[Na+].[Na+].OC1O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H](O)[C@H]1O
• InChI: 1S/C6H13O9P.2Na.H2O/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8;;;/h2-10H,1H2,(H2,11,12,13);;;1H2/q;2*+1;/p-2/t2-,3-,4+,5-,6?;;;/m1.../s1
• InChI key: UUWJZXLTPORJKW-WYFATIGWSA-L

Description

General description

Disodium salt

Application

Substrate for glucose-6-phosphatase.

Biochem/physiol Actions

In mammals, glucose-6-phosphate (G6P) is formed by a kinase acting on glucose. It plays several roles and has its fate determined accordingly. It can get converted back to glucose by a phosphatase enzyme. It can pass into glycogen, or enter into the energy-yielding Embden-Meyerhof path or into the 6-phosphogluconate pathway. Increased levels of blood glucose result in elevated levels of glucose 6-phosphate in liver, skeletal muscle, and adipose tissue. This elevated intracellular level of G6P activates glycogen synthase. G6P may also be involved in the negative regulation of phosphorylation of glycogen synthase via cyclic AMP-stimulated protein kinase.

Preparation Note

77% glucose-6-P (enzymatic), 13% sodium, 8% water

C₆H₁₁O₉PNa₂

Analysis Note

Contaminants: <0.2% glucose (enzymatic)

Other Notes

For life science research only. Not for use in diagnostic procedures.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: does not flash
• flash_point_c: does not flash