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10652202001

Roche

Transferrin

from human serum

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Synonym(s):
serum glycoprotein, transferrin

Quality Level

sterility

0.2 μm filtered

form

solution

packaging

pkg of 20 mL (30 mg/ml)

manufacturer/tradename

Roche

technique(s)

cell culture | mammalian: suitable

color

clear red

solubility

water: miscible

UniProt accession no.

storage temp.

2-8°C

Gene Information

human ... TF(7018)

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This Item
T8158T203611074547001
Transferrin from human serum

Roche

10652202001

Transferrin

Sigma-Aldrich

Sigma-Aldrich

T8158

Transferrin human

apo-Transferrin human powder, BioReagent, suitable for cell culture, ≥98% (agarose gel electrophoresis)

Sigma-Aldrich

T2036

apo-Transferrin human

form

solution

form

powder

form

powder

form

lyophilized

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

solubility

water: miscible

solubility

H2O: 50 mg/mL

solubility

H2O: 50 mg/mL

solubility

water: miscible

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

Quality Level

100

Quality Level

-

Quality Level

200

Quality Level

100

General description

Transferrin is a serum glycoprotein that participates in the transport of iron from absorption and storage sites to tissue cells. The iron-bound transferrin, also referred to as ferrotransferrin, binds to specific cell surface receptors on growing cells and are internalized by endocytosis. Once inside, the iron is released into the cells and the iron-free transferrin, also referred to as apotransferrin, is exocytosed outside the cell without being degraded.

Application

Transferrin, similar to insulin, is a component of most serum-free media formulations. The main function of transferrin is to transport iron into cells by receptor-mediated endocytosis.
Transferrin from human serum has been used as a supplement in:
  • differentiation medium
  • keratinocyte medium
  • haemogenic endothelium culture medium
  • embryoid-body medium
  • blast colony forming cell-culture medium

Physical form

Solution, 30 mg/ml in IMDM, filtered through 0.2 μm pore size membrane. Iron saturation is below 1%. This product is Apo-Transferrin.

Preparation Note

Working concentration: 1 to 100 μg/ml

Storage and Stability

Store at 2 to 8 °C. (lyophilizate and solution)

Other Notes

For life science research only. Not for use in diagnostic procedures.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

No data available

Flash Point(C)

No data available


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Proceedings of the National Academy of Sciences of the United States of America, 80(8), 2258-2262 (1983-04-01)
At pH 5.4 apotransferrin (iron-free transferrin) binds to cell-surface transferrin receptors to the same extent and with the same affinity as does diferric transferrin at pH 7.0. Apotransferrin is quickly dissociated from its receptor when the pH is raised to

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