Zhongchun Tong et al.
Experimental and therapeutic medicine, 14(6), 5491-5496 (2017-12-30)
A high prevalence of Enterococcus faecalis (E. faecalis) is observed in teeth with root canal treatment failures. Clustered regularly interspaced short palindromic repeats (CRISPR) are widely distributed in prokaryotes that have adaptive immune systems against mobile elements, including pathogenic genes....
Joris van Arensbergen et al.
Nature biotechnology, 35(2), 145-153 (2016-12-27)
Previous methods to systematically characterize sequence-intrinsic activity of promoters have been limited by relatively low throughput and the length of the sequences that could be tested. Here we present 'survey of regulatory elements' (SuRE), a method that assays more than...
Sahika Cingir Koker et al.
PloS one, 13(12), e0208982-e0208982 (2018-12-14)
Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) is an important susceptibility locus for nicotine addiction and lung cancer. Depletion of CHRNA5 has been associated with reduced cell viability, increased apoptosis and alterations in cellular motility in different cancers yet not in...
Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) RNAi is associated with cell cycle inhibition, apoptosis, DNA damage response and drug sensitivity in breast cancer
Koker SC, et al.
PLoS ONE, 13(12), e0208982-e0208982 (2018)
Li-Li Guo et al.
Experimental and therapeutic medicine, 15(6), 5394-5402 (2018-05-31)
Viral vectors represent a potential strategy for the treatment of human malignant tumors. Currently, recombinant adenovirus vectors are commonly used as gene therapy vehicles, as it possesses a proven safety profile in normal human cells. The recombinant adenovirus system has...