00020590

Supelco

1,8-Cineole

primary reference standard

Synonym(s):
Eucalyptol, 1,8-Epoxy-p-menthane, 1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane, 1,8-Cineole
Empirical Formula (Hill Notation):
C10H18O
CAS Number:
Molecular Weight:
154.25
Beilstein/REAXYS Number:
105109
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

primary reference standard

CofA

certificate is enclosed in each package

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

HWI

refractive index

n20/D 1.457 (lit.)

bp

176-177 °C (lit.)

mp

1-2 °C (lit.)

density

0.921 g/mL at 25 °C (lit.)

storage temp.

−20°C

SMILES string

C[C@]12CC[C@H](CC1)C(C)(C)O2

InChI

1S/C10H18O/c1-9(2)8-4-6-10(3,11-9)7-5-8/h8H,4-7H2,1-3H3/t8-,10+

InChI key

WEEGYLXZBRQIMU-WAAGHKOSSA-N

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General description

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.
1,8-Cineole is the main constituent of essential oils. It is a terpene oxide. It is used as percutaneous penetration enhancer, skin stimulant in skin baths, treating bronchitis, sinusitis and rheumatism. It has decongestant and antitussive property.

Application

Reference Standard in the analysis of herbal medicinal products
1,8-Cineole may have been used in quantitative analysis of volatile and semi-volatile compounds of Salvia officinalis using GC-MS method.

Pictograms

FlameExclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

RIDADR

UN 1993C 3 / PGIII

WGK Germany

WGK 2

Flash Point(F)

125.6 °F - closed cup

Flash Point(C)

52 °C - closed cup

Certificate of Analysis

Certificate of Origin

Capillary gas chromatography-mass spectrometry of volatile and semi-volatile compounds of Salvia officinalis.
Radulescu V, Chiliment S, Oprea E.
Journal of Chromatography A, 1027(1-2), 121-126 (2004)
Antiinflammatory and antinociceptive effects of 1,8-cineole a terpenoid oxide present in many plant essential oils.
Santos FA, Rao VS.
Phytotherapy Research, 14(4), 240-244 (2000)
Anke Fähnrich et al.
Plant molecular biology, 85(1-2), 135-145 (2014-02-05)
Nicotiana species of the section Alatae emit a characteristic floral scent comprising the' cineole cassette' monoterpenes 1,8-cineole, limonene, myrcene, β-pinene, α-pinene, sabinene and α-terpineol. All previously isolated 'cineole cassette'-monoterpene synthase genes are multi product enzymes that synthesize the seven compounds...
Jossana Pereira de Sousa et al.
International journal of food microbiology, 158(1), 9-13 (2012-07-17)
This study aimed to investigate the effects of sublethal concentrations of carvacrol (CAR) and 1,8-cineole (CIN) alone and in combination on the morphology, cell viability and membrane permeability of Pseudomonas fluorescens ATCC 11253 cultivated in a vegetable-based broth. Transmission and...
Xun Hu et al.
Bioresource technology, 123, 249-255 (2012-09-04)
Bio-oil from pyrolysis of mallee (Eucalyptus loxophleba ssp. gratiae) leaves differs from that obtained with wood by its content of cyclic ethers, terpenoids and N-containing organic compounds. Upgrading of the leaf bio-oil in methanol with a solid acid catalyst was...
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