00170580

Ginsenoside Rb1

primary reference standard

• Synonym(s): 2-O-β-Glucopyranosyl-(3β,12β)-20-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl β-D-glucopyranoside, Arasaponin E1, Gynosaponin C, Gypenoside III, Notoginsenoside Rb1, Panaxoside Rb1, Sanchinoside E1, Sanchinoside Rb1
• Empirical Formula (Hill Notation): C₅₄H₉₂O₂₃
• CAS Number: 41753-43-9
• Molecular Weight: 1109.29
• EC Number: 255-532-8
• MDL number: MFCD00133367
• UNSPSC Code: 85151701
• PubChem Substance ID: 329747011
• NACRES: NA.24

Properties

• grade: primary reference standard
• shelf life: limited shelf life, expiry date on the label
• manufacturer/tradename: HWI
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• SMILES string: C\C(C)=C\CC[C@](C)(O[C@@H]1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O)[C@H]3CC[C@]4(C)[C@@H]3[C@H](O)C[C@@H]5[C@@]6(C)CC[C@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)C(C)(C)[C@@H]6CC[C@@]45C
• InChI: 1S/C54H92O23/c1-23(2)10-9-14-54(8,77-48-44(69)40(65)37(62)29(74-48)22-70-46-42(67)38(63)34(59)26(19-55)71-46)24-11-16-53(7)33(24)25(58)18-31-51(5)15-13-32(50(3,4)30(51)12-17-52(31,53)6)75-49-45(41(66)36(61)28(21-57)73-49)76-47-43(68)39(64)35(60)27(20-56)72-47/h10,24-49,55-69H,9,11-22H2,1-8H3/t24-,25+,26+,27+,28+,29+,30-,31+,32-,33-,34+,35+,36+,37+,38-,39-,40-,41-,42+,43+,44+,45+,46+,47-,48-,49-,51-,52+,53+,54-/m0/s1
• InChI key: GZYPWOGIYAIIPV-JBDTYSNRSA-N

Description

General description

Produced and qualified by HWI pharma services GmbH.
Exact content measured by quantitative NMR can be found on the certificate.

Ginsenoside Rb₁ is one of the primary constituents of traditional Chinese medicine, Ginseng. It belongs to the group of triterpene saponins called ginsenosides and pharmacologically, it is one of the most active dammarane-type ginsenosides. It is known to have anti-tumor, anti-oxidant, anti-inflammatory, and cytoprotective properties.

Application

The primary reference standard can be used for identification, assay, and purity testing, method development, and validation.It can also be used as follows:

• Development and validation of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of ginsenoside Rb₁, naringin, ginsenoside Rb₂, and oridonin in rat plasma samples after administrating them weifuchun tablets
• Multi-residue analysis of baicalin, baicalein, wogonoside, wogonin, scutellarin, berberine, coptisine, ginsenoside Rb₁, and ginsenoside Re in biological samples of rat plasma by liquid chromatographic-tandem mass spectrometric (LC/MS/MS) method
• Analysis of traditional Chinese herbal decoctions of Dushen Tang and Shenfu Tang for the quantification of 12 ginsenosides by UPLC-MS/MS technique
• Analysis of rhizomes and roots of ginseng for the detection of 131 ginsenosides by UHPLC combined with a diode-array detector and quadrupole/time of flight tandem mass spectrometry (DAD-QTOF-MS/MS), along with the further determination of 19 ginsenosides by HPLC coupled with electrospray ionization-mass spectrometric detection

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable