01338

Bergamottin

analytical standard

• Synonym(s): Bergamotine, Bergaptin
• Empirical Formula (Hill Notation): C₂₁H₂₂O₄
• CAS Number: 7380-40-7
• Molecular Weight: 338.40
• Beilstein: 1353914
• MDL number: MFCD00017409
• PubChem Substance ID: 329747253
• NACRES: NA.24

Properties

• grade: analytical standard
• Quality Level: 100
• Assay: ≥98.0% (HPLC)
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 75-80 °C
• application(s): food and beverages
• format: neat
• storage temp.: 2-8°C
• SMILES string: C\C(C)=C\CC\C(C)=C\COc1c2C=CC(=O)Oc2cc3occc13
• InChI: 1S/C21H22O4/c1-14(2)5-4-6-15(3)9-11-24-21-16-7-8-20(22)25-19(16)13-18-17(21)10-12-23-18/h5,7-10,12-13H,4,6,11H2,1-3H3/b15-9+
• InChI key: DBMJZOMNXBSRED-OQLLNIDSSA-N

Description

General description

Bergamottin, a member of the furanocoumarin family, is primarily found in grapefruit juice. It is reported to be a novel signal transducer and activator of the transcription 3 (STAT3) inhibitor. It is a known drug inhibitor of cytochrome P450 34A and also exhibits diverse anti-tumor and anti-inflammatory activities.

Application

Bergamottin may be used as an analytical standard to test its efficacy in the following:

• Blocker of STAT3 activation pathway in tumor cells; its potential in the therapy of multiple myeloma (MM) and other cancers is investigated.
• Prevention and the treatment of cancer via suppression of the NF-kB signaling pathway and its regulated gene products.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves