03417

Supelco

N-2-(4-Hydroxyphenyl)acetylglycine

analytical standard

Synonym(s):
2-2-(4-Hydroxyphenyl)acetamidoacetic acid, 4-Hydroxyphenylacetyl glycine
Empirical Formula (Hill Notation):
C10H11NO4
CAS Number:
Molecular Weight:
209.20
Beilstein/REAXYS Number:
3298883
MDL number:
PubChem Substance ID:
NACRES:
NA.24
Pricing and availability is not currently available.

grade

analytical standard

Quality Level

assay

≥98.0% (HPLC)

CofA

certificate is enclosed in each package

shelf life

limited shelf life, expiry date on the label

format

neat

storage temp.

2-8°C

SMILES string

OC(CNC(CC1=CC=C(O)C=C1)=O)=O

Biochem/physiol Actions

Hydroxyphenylacetylglycine is an acylglycine. Acylglycines are normally minor metabolites of fatty acids. However, the excretion of certain acylglycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction: acyl-CoA + glycine ↔ CoA + N-acylglycine. Hydroxyphenylacetylglycine is an endogenous human metabolite. It can be originated from the metabolism of tyramine, itself is a monoamine compound derived from the amino acid tyrosine. Hydroxyphenylacetylglycine can also be derived from the metabolism of 3,4-dihydroxyphenylalanine (L-DOPA). In the metabolism of tyrosine, this compound is involved in the reaction Hydroxyphenylacetyl-CoA + Glycine ↔ Hydroxyphenylacetylglycine + CoA, catalyzed by acyltransferase enzymes (EC 2.3.1.-). Hydroxyphenylacetylglycine has been identified in human biofluids.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Certificate of Analysis
Certificate of Origin
B L Goodwin et al.
Xenobiotica; the fate of foreign compounds in biological systems, 8(10), 629-651 (1978-10-01)
The metabolism and interrelationships of orally and intraperitoneally administered L-dopa, related amino acids and their metabolites have been studied 2. Amino acids were decarboxylated. N-Methyldopa formed dopamine but not epinine. D-Dopa was absorbed from the intestine and metabolized by a...
NEW METABOLITES OF P-TYRAMINE FROM THE URINE OF RATS.
T NAKAJIMA et al.
Biochimica et biophysica acta, 90, 37-44 (1964-07-15)
H S Ramsdell et al.
Biomedical mass spectrometry, 4(4), 220-225 (1977-08-01)
The mass spectra of the methyl esters of twenty-one metabolically important N-acylglycines are reported. The spectra are discussed in terms of their fragmentations and their application to studies of metabolic diseases. In particular, the high relative abundance of the peak...
K Tanaka et al.
Clinical chemistry, 26(13), 1847-1853 (1980-12-01)
A gas-chromatographic method for urinary organic acid analysis is described, designed to be used routinely for the diagnosis of organic aciduria. It involves extraction of urine with ethyl acetate, dehydration of extract residues, and trimethylsilylation. Organic acids are identified by...
K Tanaka et al.
Clinical chemistry, 26(13), 1839-1846 (1980-12-01)
Gas-chromatographic retention indices are given, in terms of methylene units, for 155 metabolically important compounds (mostly organic acids) as trimethylsilyl derivatives on 10% OV-1 and 10% OV-17 columns. Comprehensive references on metabolic diseases that can be diagnosed by detection of...

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