03620

Sigma-Aldrich

Ethylenediaminetetraacetic acid

≥98.0% (KT)

Synonym(s):
Edathamil, (Ethylenedinitrilo)tetraacetic acid, EDTA, Ethylenedinitrilotetraacetic acid
Linear Formula:
(HO2CCH2)2NCH2CH2N(CH2CO2H)2
CAS Number:
Molecular Weight:
292.24
Beilstein/REAXYS Number:
1716295
EC Number:
MDL number:
eCl@ss:
39030907
PubChem Substance ID:
NACRES:
NA.21

Quality Level

assay

≥98.0% (KT)

form

powder

mp

250 °C (dec.) (lit.)

solubility

water: soluble 0.4 g/L at 20 °C

SMILES string

OC(=O)CN(CCN(CC(O)=O)CC(O)=O)CC(O)=O

InChI

1S/C10H16N2O8/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20)

InChI key

KCXVZYZYPLLWCC-UHFFFAOYSA-N

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General description

Ethylenediaminetetraacetic acid (EDTA, N,N,N′,N′-ethylenediaminetetraacetic acid) is a chelating agent. It forms complexes with rare earth metal ions and the stability constants of these complexes have been evaluated. Hydroxyl radicals generated pulse radiolytically in N2O- and N2O-O2-saturated solutions reacts with EDTA. Absorption spectrum of this reaction was recorded and maxima was observed at 275 and 480nm. EDTA is an excellent ligand for Cd(II) and forms stable Cd-EDTA complexes. 113Cd NMR studies of Cd-EDTA complexes have been reported.

Application

Ethylenediaminetetraacetic acid (EDTA) may be employed in a microtiter plate assay. In this assay, interaction between EDTA or lactoferrin and nisin, lysozyme, or monolaurin against Listeria monocytogenes, Escherichia coli, Salmonella enteritidis, and Pseudomonas fluorescens strains was investigated.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

WGK Germany

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

The stability of the rare earth complexes with ethylenediaminetetraacetic acid.
Wheelwright EJ, et al.
Journal of the American Chemical Society, 75(17), 4196-4201 (1953)
Hobel B and von Sonntag C.
J. Chem. Soc. Perkin Trans. II, 3, 509-514 (1998)
Jill K Branen et al.
International journal of food microbiology, 90(1), 63-74 (2003-12-16)
A microtiter plate assay was employed to systematically assess the interaction between ethylenediaminetetraacetic acid (EDTA) or lactoferrin and nisin, lysozyme, or monolaurin against strains of Listeria monocytogenes, Escherichia coli, Salmonella enteritidis, and Pseudomonas fluorescens. Low levels of EDTA acted synergistically...
Cadmium-113 nuclear magnetic resonance studies of cadmium-ethylenediaminetetraacetic acid complexes.
Jensen CF, et al.
Journal of the American Chemical Society, 103(13), 3659-3666 (1981)
Des R Richardson et al.
Journal of medicinal chemistry, 49(22), 6510-6521 (2006-10-27)
There has been much interest in the development of iron (Fe) chelators for the treatment of cancer. We developed a series of di-2-pyridyl ketone thiosemicarbazone (HDpT) ligands which show marked and selective antitumor activity in vitro and in vivo. In...

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