03910590

(±)-Catechin hydrate

primary reference standard

Synonym(s):
trans-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol, trans-3,3′,4′,5,7-Pentahydroxyflavane
Empirical Formula (Hill Notation):
C15H14O6 · xH2O
Molecular Weight:
290.27 (anhydrous basis)
Beilstein/REAXYS Number:
92762
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

primary reference standard

assay

>90.0%

form

powder

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

HWI

Featured Industry

Food and Beverages

storage temp.

−20°C

SMILES string

[H]O[H].O[C@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3ccc(O)c(O)c3

InChI

1S/C15H14O6.H2O/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7;/h1-5,13,15-20H,6H2;1H2/t13-,15+;/m0./s1

InChI key

OFUMQWOJBVNKLR-NQQJLSKUSA-N

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General description

Catechin hydrate, a flavononol, belongs to the class of flavonoids. It is present in abundance in Siberian larch (Larix sibirica) and in silymarin extract of milk thistle seeds. Its potent chemopreventive action by virtue of the regulation of genes through the ARE-dependent pathway has been widely investigated. It also shows potential antioxidant activity against ovarian cancer cell growth, cellular melanogenesis, human breast cancer, etc.
Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

Application

Catechin hydrate may be used as a reference standard for the determination of the analyte in walnut leaves by high-performance liquid chromatography (HPLC).

Biochem/physiol Actions

Polyphenolic antioxidant. Used in traditional Chinese medicine.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Target Organs

Respiratory system

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

HPLC determination of phenolic acids, flavonoids and juglone in walnut leaves
Nour V, et al.
Journal of Chromatographic Science, 51(9) (2013)
T Miyazawa
BioFactors (Oxford, England), 13(1-4), 55-59 (2001-03-10)
Green tea is consumed as a popular beverage in Japan and throughout the world. During the past decade, epidemiological studies have shown that tea catechin intake is associated with lower risk of cardiovascular disease. In vitro biochemical studies have reported...
Silvia Mandel et al.
Free radical biology & medicine, 37(3), 304-317 (2004-06-30)
Neurodegeneration in Parkinson's, Alzheimer's, and other neurodegenerative diseases seems to be multifactorial, in that a complex set of toxic reactions including inflammation, glutamatergic neurotoxicity, increases in iron and nitric oxide, depletion of endogenous antioxidants, reduced expression of trophic factors, dysfunction...
Elena Roura et al.
Clinical chemistry, 52(4), 749-752 (2006-02-14)
Plant polyphenols have been studied largely because of the possibility that they might underlie the protective effects afforded by fruit and vegetable intake against cancer and other chronic diseases. Measurement of polyphenol content excreted in urine as an indicator of...
R Hursel et al.
Obesity reviews : an official journal of the International Association for the Study of Obesity, 12(7), e573-e581 (2011-03-04)
Different outcomes of the effect of catechin-caffeine mixtures and caffeine-only supplementation on energy expenditure and fat oxidation have been reported in short-term studies. Therefore, a meta-analysis was conducted to elucidate whether catechin-caffeine mixtures and caffeine-only supplementation indeed increase thermogenesis and...

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