04936

O-(6-Chlorobenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate

≥98.0% (HPLC)

• Synonym(s): 1-[Bis(dimethylamino)methylen]-5-chlorobenzotriazolium 3-oxide hexafluorophosphate, N,N,N′,N′-Tetramethyl-O-(6-chloro-1H-benzotriazol-1-yl)uronium hexafluorophosphate, HCTU
• Empirical Formula (Hill Notation): C₁₁H₁₅ClF₆N₅OP
• CAS Number: 330645-87-9
• Molecular Weight: 413.69
• NACRES: NA.22
• PubChem Substance ID: 329747994
• UNSPSC Code: 12352101
• MDL number: MFCD04973268

Properties

• Quality Segment: 200
• assay: ≥98.0% (HPLC)
• form: powder
• reaction suitability: reaction type: Coupling Reactions
• impurities: ≤0.5% water
• mp: 185-190 °C
• application(s): peptide synthesis
• functional group: amine, chloro
• SMILES string: ClC1=CC=C(N([C+](N(C)C)N(C)C)N=[N+]2[O-])C2=C1.F[P-](F)(F)(F)(F)F
• InChI: 1S/C11H15ClN5O.F6P/c1-15(2)11(16(3)4)18-17-10-7-8(12)5-6-9(10)13-14-17;1-7(2,3,4,5)6/h5-7H,1-4H3;/q+1;-1
• InChI key: ZHHGTMQHUWDEJF-UHFFFAOYSA-N

Description

Application

Reagent for:
Synthesis of near-infrared pH activatable fluorescent probes[1]
Synthesis of human β-amyloid by Fmoc chemistry[2]
Stereoselective Horner-Wadsworth-Emmons olefination[3]
Covalent ligation of fluorescent peptides to quantum dots[4]
Alkylation of human telomere sequence[5]

Other Notes

Tandem Oligonucleotide Synthesis on Solid-Phase Supports for the Production of Multiple Oligonucleotides[6]

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H317
• pcodes: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1A
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable