08984

Butyryl-L-carnitine

analytical standard

• Synonym(s): (2R)-3-Carboxy-N,N,N-trimethyl-2-(1-oxobutoxy)-1-propanaminium inner salt, Butanoyl-L-carnitine, C4-Carnitine
• Empirical Formula (Hill Notation): C₁₁H₂₁NO₄
• CAS Number: 25576-40-3
• Molecular Weight: 231.29
• MDL number: MFCD01674827
• UNSPSC Code: 41116107
• NACRES: NB.21

Properties

• grade: analytical standard
• Quality Level: 100
• assay: ≥97.0% (HPLC)
• optical activity: [α]/D -23.0±2.0°, c = 0.1 in H₂O
• shelf life: limited shelf life, expiry date on the label
• impurities: ≤10.0% water
• application(s): clinical testing
• format: neat
• storage temp.: 2-8°C
• SMILES string: C[N+](C)(C)C[C@H](OC(CCC)=O)CC([O-])=O
• InChI: 1S/C11H21NO4/c1-5-6-11(15)16-9(7-10(13)14)8-12(2,3)4/h9H,5-8H2,1-4H3/t9-/m1/s1
• InChI key: QWYFHHGCZUCMBN-SECBINFHSA-N

Description

General description

Butyryl-L-carnitine is a naturally occurring compound belonging to the acylcarnitine class of compounds as listed in the human metabolome database (HMBD).[1][2] These compounds are reported to be used as biomarkers in the diagnosis of carnitine deficiency.[3] It acts as a carrier of long chain acyl groups from activated fatty acids across the inner mitochondrial membrane into the mitochondrial matrix where they undergo β-oxidation to acetyl CoA to obtain usable energy via the citric acid cycle.

Application

Butyryl-L-carnitine may be used as an analytical reference standard for the separation and identification of underivatized butyryl-L-carnitine in human plasma samples using high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS).[4] It may also be used as an analytical reference standard for the quantification of the analyte in biological samples[5][6] using chromatography-based techniques.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable