09658

Chloro-N,N,N′,N′-tetramethylformamidinium hexafluorophosphate

≥98.0% (T)

• Synonym(s): TCFH
• Empirical Formula (Hill Notation): C₅H₁₂ClF₆N₂P
• CAS Number: 94790-35-9
• Molecular Weight: 280.58
• UNSPSC Code: 12352101
• NACRES: NA.22
• PubChem Substance ID: 329748788
• MDL number: MFCD01862891
• Beilstein/REAXYS Number: 7896715
• Assay: ≥98.0% (T)

Properties

• InChI: 1S/C5H12ClN2.F6P/c1-7(2)5(6)8(3)4;1-7(2,3,4,5)6/h1-4H3;/q+1;-1
• SMILES string: F[P-](F)(F)(F)(F)F.CN(C)\C(Cl)=[N+](\C)C
• InChI key: CUKNPSDEURGZCO-UHFFFAOYSA-N
• assay: ≥98.0% (T)
• reaction suitability: reaction type: Coupling Reactions
• mp: 99-112 °C
• application(s): peptide synthesis
• storage temp.: 2-8°C
• Quality Level: 100

Description

Application

Chloro-N,N,N′,N′-tetramethylformamidinium hexafluorophosphate can be used as a reactant for the synthesis of:

• Onium salts for use in peptide coupling.[1]
• Benzotriazole based uranium reagent, a safer replacement for coupling reagents.[2]

It can also be used as a reagent for the synthesis of:

• Cancer cell cytotoxins.[3]
• Bioconjugation reagents.[4]

Other Notes

Coupling reagent for peptide synthesis and starting material for preparing other coupling reagents[5][6]

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves