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106232

Trifluoroacetic anhydride

ReagentPlus®, ≥99%

Trifluoroacetic anhydride

Synonym(s):

TFAA

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25 G

$36.50

100 G

$72.80

4 X 100 G

$213.00

10 X 1 G

$235.00

500 G

$287.00

3 KG

$1,620.00

25 KG

$4,080.00

$36.50


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About This Item

Linear Formula:
(CF3CO)2O
CAS Number:
Molecular Weight:
210.03
UNSPSC Code:
12352100
NACRES:
NA.21
PubChem Substance ID:
EC Number:
206-982-9
Beilstein/REAXYS Number:
746197
MDL number:
Assay:
≥99%
Bp:
39.5-40 °C (lit.)
Vapor pressure:
6.28 psi ( 20 °C)

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InChI key

QAEDZJGFFMLHHQ-UHFFFAOYSA-N

InChI

1S/C4F6O3/c5-3(6,7)1(11)13-2(12)4(8,9)10

SMILES string

FC(F)(F)C(=O)OC(=O)C(F)(F)F

vapor pressure

6.28 psi ( 20 °C)

product line

ReagentPlus®

assay

≥99%

dilution

(for general lab use)

refractive index

n20/D 1.3 (lit.)

bp

39.5-40 °C (lit.)

mp

−65 °C (lit.)

density

1.511 g/mL at 20 °C (lit.)

Quality Level

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This Item
91719302031T45004
Quality Level

100, 200

Quality Level

100

Quality Level

200

Quality Level

200

assay

≥99%

assay

≥99.0% (GC)

assay

≥99.0%

assay

99%

refractive index

n20/D 1.3 (lit.)

refractive index

n20/D 1.3 (lit.)

refractive index

n20/D 1.3 (lit.)

refractive index

n20/D 1.451 (lit.)

density

1.511 g/mL at 20 °C (lit.)

density

1.511 g/mL at 20 °C (lit.)

density

1.489 g/mL at 20 °C (lit.)

density

0.79 g/mL at 25 °C (lit.)

vapor pressure

6.28 psi ( 20 °C)

vapor pressure

6.28 psi ( 20 °C)

vapor pressure

97.5 mmHg ( 20 °C)

vapor pressure

90 mmHg ( 80 °C)

mp

−65 °C (lit.)

mp

−65 °C (lit.)

mp

−15.4 °C (lit.)

mp

-

Application

For the preparation of N- and O-trifluoroacetyl derivatives of a wide range of biologically active compounds for GC analysis. Also used in the oxidation of aldehydes to acids, esters, or amides.[1] Trifluoroacetic anhydride can undergo reaction with deoxyguanosine in pyridine to give the corresponding 6-substituted-2′-deoxyguanosine derivatives.[2] It can also react with urea-hydrogen peroxide complex to generate peroxytrifluoroacetic acid, which can convert aldoximes to nitroalkanes.[3]

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

CorrosionExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A

supp_hazards

Storage Class

8B - Non-combustible corrosive hazardous materials

wgk

WGK 2

ppe

Faceshields, Gloves, Goggles


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"Synthesis of functionalized nitroalkanes by oxidation of oximes with urea-hydrogen peroxide complex and trifluoroacetic anhydride"
Ballini R, et al.
Tetrahedron Letters, 33(33), 4835- 4838 (1992)
"Synthesis of 6-substituted 2'-deoxyguanosine derivatives using trifluoroacetic anhydride in pyridine"
Fathi R, et al.
Tetrahedron Letters, 31(03), 319-321 (1990)
Albert W Xiao et al.
Nature materials, 19(6), 644-654 (2020-02-26)
The application of transition metal fluorides as energy-dense cathode materials for lithium ion batteries has been hindered by inadequate understanding of their electrochemical capabilities and limitations. Here, we present an ideal system for mechanistic study through the colloidal synthesis of
Tetrahedron Letters, 27, 3995-3995 (1986)
Angelos Halaris et al.
Journal of psychiatric research, 66-67, 118-126 (2015-05-27)
A pro-inflammatory state and a dysregulation in the tryptophan/kynurenine pathway have been documented in depression. This study examined whether treatment with the SSRI, escitalopram (ESC), could suppress inflammation and favorably shift metabolites of the kynurenine pathway in patients with major

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    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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