11569

Supelco

3,4-Dihydroxyphenylacetic acid

analytical standard

Synonym(s):
Homoprotocatechuic acid, DOPAC
Linear Formula:
(HO)2C6H3CH2CO2H
CAS Number:
Molecular Weight:
168.15
Beilstein/REAXYS Number:
2211017
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

analytical standard

assay

≥97.0% (HPLC)
97.0-103.0% (T)

form

neat

shelf life

limited shelf life, expiry date on the label

application(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

127-130 °C (lit.)

Featured Industry

Pharmaceutical

format

neat

SMILES string

OC(=O)Cc1ccc(O)c(O)c1

InChI

1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)

InChI key

CFFZDZCDUFSOFZ-UHFFFAOYSA-N

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
3,4-Dihydroxyphenylacetic acid may be used as a reference standard for the determination of 3,4-dihydroxyphenylacetic acid in rat samples by high-performance liquid chromatography with electrochemical detection.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Target Organs

Respiratory system

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Simultaneous determination of 3, 4?dihydroxyphenylalanine, 5?hydroxytryptophan, dopamine, 4?hydroxy?3?methoxyphenylalanine, norepinephrine, 3, 4?dihydroxyphenylacetic acid, homovanillic acid, serotonin, and 5?hydroxyindoleacetic acid in rat cerebrospinal fluid and brain by high?performance liquid chromatography with electrochemical detection.
Wagner J, et al.
Journal of Neurochemistry, 38(5), 1241-1254 (1982)
Xiaoli Liu et al.
Neurotoxicity research, 38(1), 27-37 (2020-03-22)
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the accumulation of Lewy bodies and loss of dopaminergic neurons in the substantia nigra pars compacta (SNpC). MPTP is widely used to generate murine PD model. In addition to classical motor...
Wanqiu Huang et al.
Journal of neurochemistry, 150(3), 282-295 (2019-05-24)
Neuroinflammation is one of the driving forces of progressive neurodegeneration in Parkinson's disease (PD). The metabolomics approach has been proved highly useful in identifying potential therapeutic targets. Here, to identify inflammation-relevant treatment targets for PD, mass spectrometry-based untargeted metabolomics was...
Kangwei Li et al.
Journal of ethnopharmacology, 250, 112487-112487 (2019-12-21)
Seahorses (Hippocampus erectus), belonging to syngnathidae of syngnathiformes, are a traditional Chinese medicine for increasing and balancing vital energy within the body and brain, as well as calming mood and improving sleep. Based on the hypothesis of monoamine neurotransmitter deficiency...
Sandy Stayte et al.
PloS one, 10(4), e0124325-e0124325 (2015-04-23)
Parkinson's disease (PD) is a chronic neurodegenerative disease characterized by a significant loss of dopaminergic neurons within the substantia nigra pars compacta (SNpc) and a subsequent loss of dopamine (DA) within the striatum. Despite advances in the development of pharmacological...

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