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131105

Sigma-Aldrich

3,6-Diaminoacridine hydrochloride

Dye content 95 %

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Synonym(s):
Proflavine hydrochloride, Proflavine monohydrochloride
Empirical Formula (Hill Notation):
C13H11N3 · HCl
CAS Number:
Molecular Weight:
245.71
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.47

Assay

94.0% (HPLC)

form

powder

composition

Dye content, 95%

mp

270 °C (dec.) (lit.)

solubility

H2O: 1 mg/mL, clear

λmax

456 nm

ε (extinction coefficient)

50000 at 260 nm in methanol

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

Cl[H].Nc1ccc2cc3ccc(N)cc3nc2c1

InChI

1S/C13H11N3.ClH/c14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;/h1-7H,14-15H2;1H

Inchi Key

PBBGTVBGXBUVLT-UHFFFAOYSA-N

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This Item
A8251A8126P3750
Acriflavine

Sigma-Aldrich

A8126

Acriflavine

form

powder

form

powder

form

powder

form

powder

composition

Dye content, 95%

composition

-

composition

-

composition

-

mp

270 °C (dec.) (lit.)

mp

260 °C (dec.) (lit.)

mp

179-181 °C

mp

268-270 °C

solubility

H2O: 1 mg/mL, clear

solubility

H2O: 1 mg/mL

solubility

H2O: 0.33 g/mL (lit.)(lit.)

solubility

ethanol: 1 mg/mL

λmax

456 nm

λmax

-

λmax

-

λmax

-

Application

3, 6-Diaminoacridine hydrochloride has been used for studying cation transfer at the liquid–liquid interface.
An intercalating dye.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Malkia A
Electrochemical Communications, 5:6, 473-479 (2003)
Anna Porfireva et al.
Nanomaterials (Basel, Switzerland), 10(5) (2020-05-14)
A DNA sensor has been developed for the determination of doxorubicin by consecutive electropolymerization of an equimolar mixture of Azure B and proflavine and adsorption of native DNA from salmon sperm on a polymer film. Electrochemical investigation showed a difference
Anirban Basu et al.
Journal of photochemistry and photobiology. B, Biology, 165, 42-50 (2016-10-22)
Interaction of proflavine with hemoglobin (Hgb) was studied employing spectroscopy, calorimetry, and atomic force microscopy. The equilibrium constant was found to be of the order 10
Anirban Basu et al.
Journal of biomolecular structure & dynamics, 38(6), 1590-1597 (2019-05-07)
The binding of proflavine, an acriflavine derivative, with the RNA polynucletodide polyadenylic acid-polyuridylic acid is investigated here to understand the structural and thermodynamic basis of the binding process. Such binding data are crucial for designing viable theraperutic agents. Spectroscopic studies
Miklós Nagy et al.
Scientific reports, 9(1), 8250-8250 (2019-06-05)
Amino-isocyanoacridines (ICAAcs), as first members of their class, turned out to be a novel, multifunctional acridine orange (AO) type dye family with a number of additional favorable properties. They have enhanced solvatochromic emission range, low quantum yields (ΦF = 2.9-0.4%) in water

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