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Supelco

BSA+TMCS

for GC derivatization, LiChropur, 93.0-97.0% (GC)

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Synonym(s):
Bis(trimethylsilyl)acetamide + Trimethylchlorosilane
PubChem Substance ID:
NACRES:
NA.22

grade

for GC derivatization

Quality Level

Assay

93.0-97.0% (GC)

quality

LiChropur

composition

trimethylchlorosilane (minor component), 3.0-5.0% GC

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

General description

BSA+TMCS combination, is one of the most commonly used silylating reagents. BSA is readily used for silylating a wide range of functional groups such as non-sterically hindered alcohols, amides, amines, amino acids, carboxylic acids, and enols. TMCS is a silylation catalyst always used with other silylation reagents to increase the reactivity in derivatization of alcohols, alkaloids, amines, biogenic amines, carboxylic acids, phenols, and steroids.

Application

Learn more in the Product Information
Suitable for the derivatization of α-ketoacids, amines, amino acids, cycloserine, histamine and metabolites, phenylethylamines, phosphatidylserines and tryptamines. BSA+TMCS may be used as a derivatizing reagent for the determination of steryl glycosides in biodiesel using gas chromatography–mass spectrometry.
Suitable for the derivatization of a-ketoacids, amines, amino acids, cycloserine, histamine and metabolites, phenylethylamines, phosphatidylserines and tryptamines.

Features and Benefits

  • BSA+TMCS has good solvent properties and can function as a silylation reagent without additional solvents.        
  • Alternatively, the mixture is very soluble in most commonly used silylation solvents.        
  • This combination is extremely sensitive to moisture and should be handled under dry conditions.

Other Notes

Powerful silylation mixture with wide applicability
Reagent for trimethylsilyl diglyceride, trimethylsilyl (TMS) and trimethylsilyl oximes.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

related product

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Flam. Liq. 2 - Skin Corr. 1A

Supplementary Hazards

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

53.6 °F - closed cup

Flash Point(C)

12 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Z. Anal. Chem., 324, 338-338 (1986)
Removal of pharmaceuticals during drinking water treatment.
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Environmental Science & Technology, 36 (17), 3855-3863 (2002)
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Journal of Pharmacological Sciences, 62, 1344-1344 (1973)
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