15256

Supelco

BSA+TMCS

for GC derivatization, LiChropur, 93.0-97.0% (GC)

Synonym(s):
Bis(trimethylsilyl)acetamide + Trimethylchlorosilane
PubChem Substance ID:
NACRES:
NA.22

Quality Level

grade

for GC derivatization

assay

3.0-5.0% (trimethylchlorosilane, minor component, GC)
93.0-97.0% (GC)

quality

LiChropur

composition

trimethylchlorosilane (minor component), 3.0-5.0% GC

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

application(s)

GC/MS: suitable
gas chromatography (GC): suitable

General description

BSA+TMCS combination, is one of the most commonly used silylating reagents. BSA is readily used for silylating a wide range of functional groups such as non-sterically hindered alcohols, amides, amines, amino acids, carboxylic acids, and enols. TMCS is a silylation catalyst always used with other silylation reagents to increase the reactivity in derivatization of alcohols, alkaloids, amines, biogenic amines, carboxylic acids, phenols, and steroids.

Application

Learn more in the Product Information
Suitable for the derivatization of α-ketoacids, amines, amino acids, cycloserine, histamine and metabolites, phenylethylamines, phosphatidylserines and tryptamines. BSA+TMCS may be used as a derivatizing reagent for the determination of steryl glycosides in biodiesel using gas chromatography–mass spectrometry.
Suitable for the derivatization of a-ketoacids, amines, amino acids, cycloserine, histamine and metabolites, phenylethylamines, phosphatidylserines and tryptamines.

Features and Benefits

  • BSA+TMCS has good solvent properties and can function as a silylation reagent without additional solvents.        
  • Alternatively, the mixture is very soluble in most commonly used silylation solvents.        
  • This combination is extremely sensitive to moisture and should be handled under dry conditions.

Other Notes

Reagent for trimethylsilyl diglyceride, trimethylsilyl (TMS) and trimethylsilyl oximes.
Powerful silylation mixture with wide applicability

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Statements

hazcat

Acute Tox. 4 Oral - Flam. Liq. 2 - Skin Corr. 1A

Supp Hazards

EUH014

storage_class_code

3 - Flammable liquids

WGK Germany

WGK 3

Flash Point(F)

53.6 °F - closed cup

Flash Point(C)

12 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

J. Heberle et al.
Silylating Agents, 2nd ed. (1995)
Ashwin Unnikrishnan et al.
Nucleic acids research, 44(22), 10644-10661 (2016-09-09)
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D.R. Knapp
Handbook of Analytical Derivatization Reactions, 202-202 (1979)
Victor Crivianu-Gaita et al.
Biosensors & bioelectronics, 78, 92-99 (2015-11-26)
There are currently no biosensors that are able to reliably detect the process of cancer metastasis. We describe the first label-free real-time ultra-high frequency acoustic wave biosensor prototype capable of detecting the breast and prostate cancer metastasis biomarker, parathyroid hormone-related...
Removal of pharmaceuticals during drinking water treatment.
Terness TA
Environmental Science & Technology, 36 (17), 3855-3863 (2002)
Articles
Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs
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