15307

Sigma-Aldrich

Chloral hydrate

meets analytical specification of Ph. Eur., BP, USP, 99.5-101%

Synonym(s):
Trichloroacetaldehyde hydrate
Linear Formula:
Cl3CCH(OH)2
CAS Number:
Molecular Weight:
165.40
Beilstein/REAXYS Number:
1698497
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

99.5-101%

quality

meets analytical specification of Ph. Eur., BP, USP

reaction suitability

reagent type: cross-linking reagent

drug control

USDEA Schedule IV

impurities

chlor alcoholate, complies
organic volatile impurities, complies (GC)
residual solvents, complies
≤0.002% heavy metals (as Pb)
≤0.1% non-volatile matter

ign. residue

≤0.1% (as SO4)

pH

3.5-5.5 (20 °C, 10%)

mp

57 °C (lit.)

anion traces

chloride (Cl-): ≤70 mg/kg

suitability

complies for appearance of solution
complies for reaction against H2SO4

SMILES string

OC(O)C(Cl)(Cl)Cl

InChI

1S/C2H3Cl3O2/c3-2(4,5)1(6)7/h1,6-7H

InChI key

RNFNDJAIBTYOQL-UHFFFAOYSA-N

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Application

Chloral hydrate is used in many protocols as a clearing agent for the microscopic examination of plant tissues without disrupting the cellular features.

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

hazcat

Acute Tox. 1 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT RE 2 Inhalation

storage_class_code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

An improved clearing and mounting solution to replace chloral hydrate in microscopic applications.
Villani T S
Applications in plant sciences, 1(5), 1300016-1300016 (2013)
Cytohistological Analyses of Mega-sporogenesis and Gametogenesis in Ovules of Limonium spp.
Rois A S and Caperta A D
Bio-protocol, 6(21) (2016)
Analyses of plant leaf cell size, density and number, as well as trichome number using cell counter plugin.
Cheng Y, et al.
Bio-protocol, 4(13) (2014)
T L Sourkes
Molecular and chemical neuropathology, 17(1), 21-30 (1992-08-01)
Chloral hydrate was introduced into therapeutics more than 120 years ago, and soon became popular as a somnifacient. It is the first synthetic CNS depressant. Its metabolite, urochloralic acid, was detected early. Studies of the biochemical pharmacology of chloral hydrate...
Nicholas M Allen et al.
Developmental medicine and child neurology, 56(2), 105-112 (2013-12-07)
Status dystonicus is a rare, but life-threatening movement disorder emergency. Urgent assessment is required and management is tailored to patient characteristics and complications. The use of dystonia action plans and early recognition of worsening dystonia may potentially facilitate intervention or...

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