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15450

Sigma-Aldrich

Boc-Leu-OH hydrate

≥99.0% (HPLC)

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Synonym(s):
Boc-L-leucine
Linear Formula:
(CH3)2CHCH2CH(COOH)NHCOOC(CH3)3 xH2O
Molecular Weight:
231.29 (anhydrous basis)
EC Number:
MDL number:
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

≥99.0% (HPLC)

form

solid

optical activity

[α]20/D −25±0.5°, c = 2% in acetic acid

reaction suitability

reaction type: Boc solid-phase peptide synthesis
reaction type: C-H Activation
reagent type: ligand
reaction type: Peptide Synthesis

mp

85-90 °C

application(s)

peptide synthesis

functional group

amine
carboxylic acid

SMILES string

CC(C)C[C@H](NC(OC(C)(C)C)=O)C(O)=O

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Boc-Leu-OH hydrate ≥99.0% (HPLC)

Sigma-Aldrich

15450

Boc-Leu-OH hydrate

Boc-Tle-OH ≥99.0% (T)

Sigma-Aldrich

15451

Boc-Tle-OH

Boc-Phe-OH ≥99.0% (T)

Sigma-Aldrich

15480

Boc-Phe-OH

Boc-Ala-OH ≥99.0% (TLC)

Sigma-Aldrich

15380

Boc-Ala-OH

form

solid

form

-

form

solid

form

-

optical activity

[α]20/D −25±0.5°, c = 2% in acetic acid

optical activity

[α]20/D −4.2±0.5°, c = 1% in glacial acetic acid

optical activity

[α]20/D +25±1°, c = 1% in ethanol

optical activity

[α]20/D −25±1°, c = 2% in acetic acid

mp

85-90 °C

mp

118-121 °C

mp

85-87 °C (lit.)

mp

79-83 °C (lit.)

functional group

amine, carboxylic acid

functional group

amine, carboxylic acid

functional group

amine, carboxylic acid

functional group

amine, carboxylic acid

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

Application

Boc-Leu-OH (Boc-L-leucine) was used in the synthesis of a potent cytotoxin, PM-94128.
Boc-protected leucine (Boc-Leu-OH) can be used to generate combinatorial peptide libraries and also to synthesize peptide models to study structure-activity relationships.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Masaru Enomoto et al.
The Journal of organic chemistry, 74(19), 7566-7569 (2009-09-03)
The enantioselective total synthesis of PM-94128, a potent cytotoxin of microbial origin, was accomplished by a concise nine-step sequence of reactions in 14% overall yield from N-Boc-l-leucine. The synthesis of Y-05460M-A, a one-carbon lower homologue of PM-94128, was also achieved
Screening of mixture combinatorial libraries for chiral selectors: a reciprocal chromatographic approach using enantiomeric libraries.
Wu Y, et al.
Analytical Chemistry, 71(9), 1688-1691 (1999)
Multicyclic polypeptide model compounds. 1. Synthesis of a tricyclic amphiphilic. alpha.-helical peptide using an oxime resin, segment-condensation approach.
Osapay G, et al.
Journal of the American Chemical Society, 112(16), 6046-6051 (1990)
The synthesis and screening of a combinatorial peptide library for affinity ligands for glycosylated haemoglobin1.
Chen B, et al.
Biosensors And Bioelectronics, 13(7-8), 779-785 (1998)
Hyun-Woong Cho et al.
PloS one, 14(6), e0217745-e0217745 (2019-06-21)
The aim of this study was to investigate the short-term efficacy and safety of Poly-gamma-glutamic acid (γ-PGA) and the immunologic changes in patients with CIN 1. Participants were randomly assigned to one of two groups and orally treated with placebo

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